Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance

Summary

Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and-error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict IOP response to drugs.

Timeline

Start

2020-11-23

Primary completion

2025-05-22

Completion

2025-05-22

Publications

• Background Man X, Costa R, Ayres BM, Moroi SE. Acetazolamide-Induced Bilateral Ciliochoroidal Effusion Syndrome in Plateau Iris Configuration. Am J Ophthalmol Case Rep. 2016 Oct;3:14-17. doi: 10.1016/j.ajoc.2016.05.003. Epub 2016 May 17.
• Kazemi A, Reitinger JC, Toris CB, Gulati V, Fan S, Reed DM, Moroi SE, Sit AJ. Aqueous Humor Dynamics Changes and Predictors of IOP Response to Latanoprost in Healthy Subjects. J Glaucoma. 2025 Dec 1;34(12):1056-1064. doi: 10.1097/IJG.0000000000002585. Epub 2025 May 9.

Drugs

Indications