drugset

drugset / Trial / NCT04421300

A Randomized Study of Smile Exercise for Dry Eye

NCT04421300 ↗

Completed 299 enrolled Zhongshan Ophthalmic Center, Sun Yat-sen University

RandomizedParallel-groupSingle-blindTreatment

Summary

The objective of the study is to evaluate the effectiveness of laughter therapy in relieving the symptoms of dry eye disease.

Timeline

Start: 2020-07-02
Primary completion: 2021-04-02
Completion: 2021-04-02

Publications

Li J, Liao Y, Zhang SY, Jin L, Congdon N, Fan Z, Zeng Y, Zheng Y, Liu Z, Liu Y, Liang L. Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial. BMJ. 2024 Sep 11;386:e080474. doi: 10.1136/bmj-2024-080474.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Sodium Hyaluronate	Other / unclassified	0.1 %	Topical

Indications