Drugs / Sodium Hyaluronate
Sodium Hyaluronate
also known as
Hyalgan · HA35 · hyaluronate · Hylo-comod · Hyalein · hyaluronic acid · B-HA · PRO-087 · +27 more
Other / unclassified targets CD44
Trials 72 · started per year
today
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT07665619 | Jul 2026 → Dec 2027 expected | radiation cystitis | Fujian Medical University Union Hospital | Not yet recruiting | No outcome recorded |
| Phase 0 | NCT04142411 | Nov 2019 → May 2020 | carpal tunnel syndrome | Assiut University | Unknown | No outcome recorded |
| Phase 14 trials | ||||||
| Phase 1 | NCT04081610 | Sep → Oct 2019 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 1 | NCT03697876 | Aug 2018 → Jun 2024 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 1 | NCT03180125 | Aug → Oct 2017 | carpal tunnel syndrome | Assiut University | Completed | No outcome recorded |
| Phase 1 | NCT03524157 | Jul 2017 → Feb 2018 | allergic disease, dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT07688096 | Jul 2026 → Sep 2027 expected | Ehlers-Danlos syndrome, hypermobility type, chronic pain syndrome, hypermobility spectrum disorder, hypermobility syndrome | Manhattan Pain Medicine, PLLC | Not yet recruiting | No outcome recorded |
| Phase 29 trials | ||||||
| Phase 2 | NCT07413172 | Jul 2026 → Jul 2028 expected | dry eye syndrome | University of Miami | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06851364 | Oct 2022 → Feb 2023 | dry eye syndrome | International Islamic University Malaysia | Completed | No outcome recorded |
| Phase 2 | NCT04704531 | Jan → Jun 2022 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 2 | NCT02810119 | Nov 2016 → Oct 2017 | conjunctivochalasis | Ocuwize LTD | Completed | No outcome recorded |
| Phase 2 | NCT04569656 | Feb → Dec 2016 | Parkinson disease | IRCCS San Raffaele Roma | Completed | No outcome recorded |
| Phase 2 | NCT02493712 | Jan 2016 → Jul 2018 | ulcerative colitis | Holy Stone Healthcare Co., Ltd | Completed | No outcome recorded |
| Phase 2 | NCT01288001 | Mar → Dec 2011 | osteoarthritis, knee | TRB Chemedica | Completed | No outcome recorded |
| Phase 2 | NCT01267214 | Feb 2009 → Feb 2010 | osteoarthritis, knee | TRB Chemedica | Completed | No outcome recorded |
| Phase 2 | NCT00918736 | Oct 2007 → Oct 2008 | osteoarthritis | Kaohsiung Veterans General Hospital. | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT07337863 | Aug → Sep 2026 expected | osteoarthritis, knee | Universitas Sriwijaya | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT06999993 | Jun 2025 → May 2026 overdue | — | Misr University for Science and Technology | Active not recruiting | No outcome recorded |
| Phase 313 trials | ||||||
| Phase 3 | NCT06803654 | May → Jun 2025 | ocular hyperemia | Bausch & Lomb Incorporated | Completed | No outcome recorded |
| Phase 3 | NCT06684626 | Mar → Jul 2024 | chronic prostatitis | Federico II University | Completed | No outcome recorded |
| Phase 3 | NCT06461975 | Jan → Apr 2023 | retinopathy of prematurity | Alexandria University | Completed | No outcome recorded |
| Phase 3 | NCT04711642 | Jan 2021 → Jan 2022 | cataract, dry eye syndrome | Fundación Oftalmológica Los Andes | Unknown | No outcome recorded |
| Phase 3 | NCT03515187 | Jun 2018 → Apr 2021 | dry eye syndrome | Shenzhen Hospital of Southern Medical University | Unknown | No outcome recorded |
| Phase 3 | NCT02258295 | Jan 2017 → Sep 2019 | epicondylitis | Shaare Zedek Medical Center | Completed | No outcome recorded |
| Phase 3 | NCT03000556 | Sep 2016 → Dec 2018 | corneal disorder | Fang Duan | Unknown | No outcome recorded |
| Phase 3 | NCT01382225 | Jul 2011 → May 2012 | dry eye syndrome | Alcon Research | Completed | No outcome recorded |
| Phase 3 | NCT00750724 | Jul 2008 → Sep 2009 | osteoarthritis | Khon Kaen University | Completed | No outcome recorded |
| Phase 3 | NCT00599716 | Dec 2006 → Apr 2008 | dry eye syndrome | Lantibio | Completed | No outcome recorded |
| Phase 3 | NCT00323778 | May 2006 → Sep 2007 | osteoarthritis, knee | Hospital for Special Surgery, New York | Terminated | No outcome recorded |
| Phase 3 | NCT00330135 | Jan 2005 → Mar 2007 | osteoarthritis, hip | Daiichi Sankyo | Terminated | No outcome recorded |
| Phase 3 | NCT00377624 | Jan 2002 → Sep 2004 | osteoarthritis | Sanofi | Completed | No outcome recorded |
| Phase 414 trials | ||||||
| Phase 4 | NCT07280442 | Jan → Dec 2026 expected | lichen planus, oral | Universidad Complutense de Madrid | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07308015 | Jun 2025 → Jun 2026 overdue | rhinitis | China-Japan Union Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT06860659 | Sep 2024 → May 2025 overdue | dry eye syndrome | Department of Medical Services Ministry of Public Health of Thailand | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT05591651 | Jan 2023 → Dec 2025 overdue | — | Specijalisticka Pedijatrijska Ordinacija prim.mr.sc. Maja Stimac, Specijalist Pedijatrije Sspecijalnosti Neonatologije | Recruiting | No outcome recorded |
| Phase 4 | NCT04441528 | Nov 2018 → Nov 2019 | blepharitis | Istanbul University - Cerrahpasa | Completed | No outcome recorded |
| Phase 4 | NCT03319420 | Mar 2018 → Jan 2021 | dry eye syndrome | Ocuwize LTD | Completed | No outcome recorded |
| Phase 4 | NCT03223909 | Oct 2016 → Oct 2018 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 4 | NCT02826031 | Apr 2016 → Oct 2017 | osteoarthritis, knee | Kunming Baker Norton Pharmaceutical Sales Co., Ltd. | Unknown | No outcome recorded |
| Phase 4 | NCT02595606 | Sep 2015 → Mar 2016 | diabetes mellitus, dry eye syndrome | Sun Yat-sen University | Unknown | No outcome recorded |
| Phase 4 | NCT00422643 | Mar → Oct 2007 | osteoarthritis, knee | Assaf-Harofeh Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT00830830 | Dec 2005 → Oct 2006 | osteoarthritis | Sanofi | Completed | No outcome recorded |
| Phase 4 | NCT00130468 | Nov 2004 → May 2006 | osteoarthritis, knee | Sanofi | Completed | No outcome recorded |
| Phase 4 | NCT00144820 | May 1999 → Nov 2001 | osteoarthritis, knee | Glostrup University Hospital, Copenhagen | Unknown | No outcome recorded |
| Phase 4 | NCT00493662 | — | dry eye syndrome | Innovative Medical | Completed | No outcome recorded |
| Phase not applicable27 trials | ||||||
| — | NCT07524725 | Jan 2027 → Dec 2032 expected | dry eye syndrome | Zhongshan Ophthalmic Center, Sun Yat-sen University | Not yet recruiting | No outcome recorded |
| — | NCT07097922 | Aug 2025 → May 2026 overdue | dry eye syndrome | He Eye Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06656403 | Oct → Nov 2024 overdue | dry eye syndrome | He Eye Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06444035 | May → Oct 2024 | chronic ulcer of skin, myofascial pain syndrome | Nakhia Impex LLC | Unknown | No outcome recorded |
| — | NCT07412535 | Mar → Oct 2024 | — | Mansoura University | Completed | No outcome recorded |
| — | NCT06209970 | Dec 2023 → Feb 2024 | — | Nakhia Impex LLC | Completed | No outcome recorded |
| — | NCT06082531 | Sep 2023 → Dec 2025 overdue | articular cartilage disorder, osteoarthritis, knee | Xijing Hospital | Recruiting | No outcome recorded |
| — | NCT06798025 | Jul 2023 → Jun 2024 | stenosis of lacrimal punctum | Tanta University | Completed | No outcome recorded |
| — | NCT05809700 | Jun → Jul 2023 | neuropathy, painful | Dove Medical Press Ltd | Completed | No outcome recorded |
| — | NCT06865092 | May 2023 → Nov 2025 | gingival overgrowth | University of Health Sciences | Completed | No outcome recorded |
| — | NCT05810649 | Apr → Aug 2023 | chronic ulcer of skin | Nakhia Impex LLC | Completed | No outcome recorded |
| — | NCT05765513 | Feb → Jul 2023 | periodontitis | Dove Medical Press Ltd | Completed | No outcome recorded |
| — | NCT07066527 | Jun 2022 → Dec 2025 overdue | vascular malformation | Qilu Hospital of Shandong University | Recruiting | No outcome recorded |
| — | NCT05032924 | Aug 2021 → Jul 2024 | rotator cuff syndrome | Chang Gung Memorial Hospital | Unknown | No outcome recorded |
| — | NCT04681937 | Jun → Nov 2021 | rotator cuff syndrome | Bezmialem Vakif University | Unknown | No outcome recorded |
| — | NCT04667819 | Dec 2020 → Dec 2021 | dry eye syndrome | Tianjin Eye Hospital | Unknown | No outcome recorded |
| — | NCT04668131 | Sep 2020 → Mar 2022 | dry eye syndrome | Peking University Third Hospital | Completed | No outcome recorded |
| — | NCT05756595 | Jul 2020 → Dec 2022 | herpes zoster | Dove Medical Press Ltd | Completed | No outcome recorded |
| — | NCT05764226 | Jul 2020 → Dec 2022 | chronic ulcer of skin | Nakhia Impex LLC | Completed | No outcome recorded |
| — | NCT04000789 | Jul → Dec 2019 | dry eye syndrome, proliferative diabetic retinopathy | Dr Cipto Mangunkusumo General Hospital | Unknown | No outcome recorded |
| — | NCT03365388 | Apr 2018 → Apr 2020 | periarthritis | Peking University People's Hospital | Unknown | No outcome recorded |
| — | NCT02817191 | Jun → Nov 2016 | senile cataract | Sun Yat-sen University | Unknown | No outcome recorded |
| — | NCT01284439 | Jan 2011 → Jan 2012 | eye adnexa disorder, glaucoma | Mahidol University | Unknown | No outcome recorded |
| — | NCT01101984 | Feb 2010 → Apr 2012 | dry eye syndrome | Santen Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| — | NCT00969501 | Aug 2009 → Aug 2010 | osteoarthritis | Georgia Institute for Clinical Research, LLC | Completed | No outcome recorded |
| — | NCT00570648 | Jun 2007 → Jun 2008 | corneal disorder | University of Virginia | Completed | No outcome recorded |
| — | NCT01363414 | Jan 2007 → Jun 2010 | dry eye syndrome | Ramathibodi Hospital | Completed | No outcome recorded |
Also used as a comparator or background therapy in 59 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 03 trials | ||||||
| Phase 0 | NCT05018481 Comparator | Sep 2022 → Oct 2026 expected | alcoholic hepatitis | The Cleveland Clinic | Recruiting | No outcome recorded |
| Phase 0 | NCT05025865 Comparator | Feb 2022 → Oct 2026 expected | — | The Cleveland Clinic | Recruiting | No outcome recorded |
| Phase 0 | NCT04130100 Comparator | Apr 2019 → Sep 2021 | osteoarthritis, knee | CAR-T (Shanghai) Biotechnology Co., Ltd. | Unknown | No outcome recorded |
| Phase 12 trials | ||||||
| Phase 1 | NCT06370585 Comparator | May → Jul 2024 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 1 | NCT05618730 Background | Sep 2022 → Dec 2023 | dry eye syndrome | Eximore Ltd. | Unknown | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT03955497 Comparator | Oct 2018 → Oct 2022 | chondromalacia, osteoarthritis, knee | Qilu Hospital of Shandong University | Unknown | No outcome recorded |
| Phase 210 trials | ||||||
| Phase 2 | NCT06614348 Comparator | Oct 2024 → Jun 2025 overdue | cataract 50 with or without glaucoma, senile cataract | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06798727 Comparator | Mar 2023 → Mar 2027 expected | osteoarthritis, knee | Medipost Co Ltd. | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06146881 Comparator | Oct 2022 → Dec 2023 | dry eye syndrome | Indonesia University | Unknown | No outcome recorded |
| Phase 2 | NCT05429229 Comparator | Nov 2021 → Dec 2023 | diabetic retinopathy, disorder of defective peroxisome oxidative status, dry eye syndrome | Adolfo Daniel Rodriguez-Carrizalez | Unknown | No outcome recorded |
| Phase 2 | NCT03028428 Comparator | Dec 2016 → Dec 2018 | osteoarthritis, knee | Affiliated Hospital of Jiangsu University | Unknown | No outcome recorded |
| Phase 2 | NCT02855073 Comparator | Jul 2014 → Dec 2019 | articular cartilage disorder, osteoarthritis, knee | Shanghai AbelZeta Ltd. | Unknown | No outcome recorded |
| Phase 2 | NCT02162693 Comparator | Nov 2013 → May 2016 | osteoarthritis, knee | Shanghai AbelZeta Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT01493180 Comparator | Dec 2011 → Nov 2012 | keratoconjunctivitis | Otsuka Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT01135511 Comparator | Jul 2010 → Apr 2011 | dry eye syndrome | Pfizer | Completed | No outcome recorded |
| Phase 2 | NCT00760045 Comparator | Aug → Oct 2008 | dry eye syndrome | Alcon Research | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT05912946 Comparator | Oct 2023 → Oct 2024 | interstitial cystitis | West China Hospital | Unknown | No outcome recorded |
| Phase 2/3 | NCT01735058 Comparator | Feb → Dec 2012 | shoulder impingement syndrome | Isfahan University of Medical Sciences | Unknown | No outcome recorded |
| Phase 35 trials | ||||||
| Phase 3 | NCT06570291 Comparator | Feb 2025 → Dec 2026 expected | osteoarthritis, knee | Wuxi Cellular Biopharmaceutical Group Ltd. | Recruiting | No outcome recorded |
| Phase 3 | NCT02777723 Comparator | May → Jul 2016 | dry eye syndrome | Chong Kun Dang Pharmaceutical | Unknown | No outcome recorded |
| Phase 3 | NCT01510535 Comparator | Dec 2011 → Mar 2012 | osteoarthritis, knee | LG Life Sciences | Completed | No outcome recorded |
| Phase 3 | NCT00885079 Comparator | May 2009 → Mar 2010 | dry eye syndrome | Otsuka Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT01240382 Comparator | ? → Feb 2008 | dry eye syndrome | Santen Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 416 trials | ||||||
| Phase 4 | NCT07679685 Comparator | Jun 2026 → Feb 2027 expected | dry eye syndrome | Beijing Tongren Hospital | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07405840 Comparator | Jun 2025 → Aug 2026 overdue | osteoarthritis | Clinical Center of Vojvodina | Active not recruiting | No outcome recorded |
| Phase 4 | NCT06279507 Comparator | Feb 2024 → Jan 2025 | osteoarthritis, knee | Phramongkutklao College of Medicine and Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT05603468 Comparator | Dec 2022 → Dec 2026 expected | disease of the tendon | Second Affiliated Hospital, School of Medicine, Zhejiang University | Active not recruiting | No outcome recorded |
| Phase 4 | NCT04704518 Comparator | Sep 2022 → Dec 2023 | — | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 4 | NCT04702776 Comparator | Dec 2021 → May 2023 | dry eye syndrome | Laboratorios Sophia S.A de C.V. | Completed | No outcome recorded |
| Phase 4 | NCT05771194 Comparator | Feb 2021 → Mar 2022 | eyelid disorder | Tianjin Medical University Eye Hospital | Completed | No outcome recorded |
| Phase 4 | NCT04557943 Comparator | Sep 2019 → Apr 2020 | osteoarthritis, knee | Hasanuddin University | Completed | No outcome recorded |
| Phase 4 | NCT03318874 Background | Oct 2017 → Apr 2020 | dry eye syndrome | Oslo University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT02640144 Comparator | Feb 2017 → Feb 2018 | articular cartilage disorder | Ziv Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT02323451 Comparator | Dec 2014 → Aug 2016 | osteoarthritis, knee | Shanghai Qisheng Biological Preparation Co., Ltd. | Unknown | No outcome recorded |
| Phase 4 | NCT02117687 Comparator | May 2014 → Jan 2015 | dry eye syndrome | Allergan | Completed | No outcome recorded |
| Phase 4 | NCT00987727 Comparator | Nov 2009 → Jul 2010 | dry eye syndrome | Allergan | Completed | No outcome recorded |
| Phase 4 | NCT00938704 Comparator | Jun 2009 | dry eye syndrome | Allergan | Completed | No outcome recorded |
| Phase 4 | NCT00763360 Comparator | May 2008 → Sep 2010 | cataract | Alcon Research | Completed | No outcome recorded |
| Phase 4 | NCT00761202 Comparator | Aug 2007 → Jun 2008 | dry eye syndrome | Allergan | Completed | No outcome recorded |
| Phase not applicable20 trials | ||||||
| — | NCT07536971 Comparator | May 2026 → Dec 2028 expected | adhesions of uterus | Beijing Obstetrics and Gynecology Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06818487 Background | Jul 2025 → Jan 2027 expected | dry eye syndrome | Beijing Tongren Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06981104 Comparator | Nov 2024 → Feb 2025 | asthenopia, dry eye syndrome | Second Affiliated Hospital, School of Medicine, Zhejiang University | Completed | No outcome recorded |
| — | NCT06576245 Background | Sep 2023 → Feb 2024 | dry eye syndrome | University of Seville | Completed | No outcome recorded |
| — | NCT07373730 Comparator | Aug 2023 → Jun 2024 | temporomandibular joint disorder | Suez Canal University | Completed | No outcome recorded |
| — | NCT05861570 Comparator | May 2023 → Apr 2024 | frozen shoulder | Taipei Veterans General Hospital, Taiwan | Unknown | No outcome recorded |
| — | NCT07033312 Comparator | Apr 2023 → Feb 2025 | osteoarthritis, knee | Taichung Veterans General Hospital | Completed | No outcome recorded |
| — | NCT04980144 Comparator | Mar → Aug 2023 | — | He Eye Hospital | Unknown | No outcome recorded |
| — | NCT05682547 Comparator | Dec 2022 → Jun 2023 | — | He Eye Hospital | Completed | No outcome recorded |
| — | NCT05257213 Comparator | Feb 2022 → Feb 2026 overdue | adhesions of uterus | Nadezhda Women's Health Hospital | Recruiting | No outcome recorded |
| — | NCT05130814 Background | Dec 2021 → Mar 2024 | decubitus ulcer | Emoled | Completed | No outcome recorded |
| — | NCT06696625 Background | Jul 2021 → Nov 2025 overdue | dry eye syndrome | Beijing Tongren Hospital | Recruiting | No outcome recorded |
| — | NCT04421300 Comparator | Jul 2020 → Apr 2021 | dry eye syndrome | Zhongshan Ophthalmic Center, Sun Yat-sen University | Completed | No outcome recorded |
| — | NCT05385562 Comparator | Jan 2020 → May 2022 | macular retinal edema | Al-Azhar University | Completed | No outcome recorded |
| — | NCT03705949 Comparator | Sep 2017 → Sep 2018 | cataract | Democritus University of Thrace | Completed | No outcome recorded |
| — | NCT03640351 Comparator | Aug 2017 → Feb 2019 | cataract, dry eye syndrome | Yonsei University | Completed | No outcome recorded |
| — | NCT03116776 Comparator | May 2017 → Jul 2018 | dry eye syndrome | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Unknown | No outcome recorded |
| — | NCT02608489 Comparator | Jan 2014 → Jan 2015 | dry eye syndrome | Soonchunhyang University Hospital | Completed | No outcome recorded |
| — | NCT02147509 Background | Mar 2013 → Apr 2014 | Sjogren syndrome | Jinyang Li | Completed | No outcome recorded |
| — | NCT01760577 Comparator | May 2010 → May 2012 | osteoarthritis | Kaohsiung Veterans General Hospital. | Completed | No outcome recorded |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2019-07-01 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Announces Launch of 1% Sodium Hyaluronate in the United States tevapharm.com ↗ |
Evidence & citations 39 cited values
Every value below carries the sentence it was read from. 134 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | sodium hyaluronate | “Patients were treated with a combination of punctal dilation and topical medication in the form of preservative-free steroid eye drops based on dexamethasone sodium phosphate...” NCT06798025 ↗107“After the screening visits, eligible patients will be randomized to 1 of 3 study groups: (1) IBD98 M 0.8 g/day (mesalamine 0.8 g with sodium hyaluronate 92 mg), (2) IBD98 M 1.2...” NCT02493712 ↗ “Participants will receive a single intra-articular injection of high-molecular-weight hyaluronic acid (Reviscon Re-Cross, MV Pharm; 88 mg sodium hyaluronate \[2.2%\] in 4 mL...” NCT07405840 ↗ “The hyaluronate group received intraarticular injections of 2 ml sodium hyaluronate (Hyalgan, molecular weight 500-730kDa, Fidia Pharmaceutical Corporation, Abano Terme, Italy).” NCT01760577 ↗ “arm1: sodium hyaluronate (4ml) arm2: platelet-rich-plasma (4ml) arm3: methylprednisolone acetate (1ml methylprednisolone acetate + 3 ml serum saline) arm4: serum saline (4ml)” NCT04681937 ↗ “given 0.1% sodium hyaluronate eye drops 4 times daily for 3 days before surgery (Jiang Xi, Zhen Shiming Pharmaceutical Co., Ltd.) and 3 months after surgery” NCT05771194 ↗ “The association with sodium hyaluronate (low molecular weight depolymerizes) rapidly attracting water and amplifying the desired clinical effect.” NCT04569656 ↗ “It consists of a preservative-free eye drop composed of sodium hyaluronate 0.4%, one drop is applied in each eye every 4 hours for a month.” NCT05429229 ↗ “Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA)” NCT00969501 ↗ “1mL prednisone (MSD) + 2mL sodium hyaluronate (biochemical Industry Co., Ltd.) was injected under arthroscopy” NCT05603468 ↗ “The hyaluronic acid preparation will contain white vaseline and 0.2% sodium hyaluronate in a 30 g container.” NCT05591651 ↗ “HYAJOINT Synovial Fluid Supplement, active ingredient: Sodium Hyaluronate 25 mg, package: 2.5 mL per syringe” NCT05032924 ↗ “0.1% sodium hyaluronate eye drops were instillation into the inferior conjunctival vault of both eyes” NCT07097922 ↗ “Preservative-free, 0.15% sodium hyaluronate (Hyabak, Théa laboratories) 4 times daily.” NCT05618730 ↗ “Brimonidine tartrate ophthalmic solution 0.025% with sodium hyaluronate (BTOS-HA)” NCT06803654 ↗ “Participants use 0.1% sodium hyaluronate eye drops 4 times per day in both eyes.” NCT07524725 ↗ “A single knee administration of Hyaluronic acid(1% Sodium Hyaluronate 20mg/2ml)” NCT06798727 ↗ “PRO-165 Chondroitin sulfate 0.18% / sodium hyaluronate 0.2%, ophthalmic gel.” NCT03697876 ↗ “2 ml biodegradable barrier gel containing sodium hyaluronate (10 mg/ml)” NCT05257213 ↗ “Dexpanthenol 2% and sodium hyaluronate 0.15% ophthalmic solution.” NCT06370585 ↗ “Artelac® Nighttime Gel (0.24% Sodium Hyaluronate with Carbomer)” NCT06576245 ↗ “0.1% Sodium hyaluronate artificial tears (preservative free)” NCT04980144 ↗ “Visco-3 Sodium Hyaluronate Viscosupplementation” NCT07688096 ↗ “sodium hyaluronate 2 mL (Hyalgan 10.3 mg/mL)” PMID 18415773 ↗ Mar 2008 “Hyalgan (sodium hyaluronate)” NCT00130468 ↗ “Hyalgan (sodium hyaluronate)” NCT00830830 ↗ “sodium hyaluronate 0.4%” NCT04081610 ↗ “SH: Sodium Hyaluronate” NCT02147509 ↗ “Sodium hyaluronate” NCT03319420 ↗ “Sodium Hyaluronate” NCT02810119 ↗ |
| Known as | 35 kDa B-HA | “METHODS: We elaborated on the production process, bioactivity assay, efficacy analyses, and safety evaluation of an injectable novel HA fragment with an average molecular...” PMID 36686276 ↗ Jan 2023 |
| Known as | ADANT | “To demonstrate the difference in terms of symptomatic efficacy between ADANT® sodium hyaluronate and placebo following an intra-articular injection” NCT00330135 ↗ |
| Known as | B-HA | “Anti-Inflammatory Effects of the 35kDa Hyaluronic Acid Fragment (B-HA/HA35).” PMID 36686276 ↗ Jan 20231“HA35 (Bioactive HA or B-HA or HA35) have good tissue permeability” NCT06209970 ↗ |
| Known as | Bioactive HA | “HA35 (Bioactive HA or B-HA or HA35) have good tissue permeability” NCT06209970 ↗ |
| Known as | EUFLEXXA | “Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA)” NCT00969501 ↗ |
| Known as | Fermathron | “Ultrasound guided injection of sodium hyaluronate; Fermathron ™, 20 mg/2ml of Sodium Hyaluronate, 3 weekly injections.” NCT01735058 ↗ |
| Known as | Gengigel | “0.8% hyaluronic acid (HA) gel (Gengigel) was applied to the wound sites.” NCT06865092 ↗ |
| Known as | HA35 | “In this study, the tissue-permeable 35 kDa HA fragment HA35 was freshly manufactured by mixing hyaluronidase PH20 injectable solution (H31022111) and high-molecular-weight HA...” NCT05810649 ↗6“the HA fragment HA35, with an average molecular weight of 35 kDa, was produced” NCT05809700 ↗ |
| Known as | Healon | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00763360 ↗ |
| Known as | Hialid | “0.1% sodium hyaluronate eye drops (Hialid®)” NCT07679685 ↗ |
| Known as | High Hyal Plus | “A single knee administration of High Hyal Plus Inj.(1% Sodium Hyaluronate 20mg/2ml)” NCT06798727 ↗ |
| Known as | High Hyal Plus Inj. | “A single knee administration of High Hyal Plus Inj.(1% Sodium Hyaluronate 20mg/2ml)” NCT06798727 ↗ |
| Known as | Hyabak | “Preservative-free, 0.15% sodium hyaluronate (Hyabak, Théa laboratories) 4 times daily.” NCT05618730 ↗ |
| Known as | HYAJOINT Synovial Fluid Supplement | “HYAJOINT Synovial Fluid Supplement, active ingredient: Sodium Hyaluronate 25 mg, package: 2.5 mL per syringe” NCT05032924 ↗ |
| Known as | Hyalein | “sodium hyaluronate (Hyalein) once weekly for 4 consecutive weeks” NCT07665619 ↗ |
| Known as | Hyalgan | “2 ml sodium hyaluronate (Hyalgan) into the ankle joints.” NCT00918736 ↗7“sodium hyaluronate 2 mL (Hyalgan 10.3 mg/mL)” PMID 18415773 ↗ Mar 2008 “Sodium Hyaluronate (Hyalgan)” NCT01267214 ↗ |
| Known as | hyaluronan | “2 ml sodium hyaluronate (hyaluronan)” NCT00144820 ↗ |
| Known as | hyaluronate | “This study will investigate the effectiveness of hyaluronate in treatment of chronic LE.” NCT02258295 ↗ |
| Known as | hyaluronic acid | “Participants will receive a single intra-articular injection of high-molecular-weight hyaluronic acid (Reviscon Re-Cross, MV Pharm; 88 mg sodium hyaluronate \[2.2%\] in 4 mL...” NCT07405840 ↗2“A single knee administration of Hyaluronic acid(1% Sodium Hyaluronate 20mg/2ml)” NCT06798727 ↗ “Sodium hyaluronate (hyaluronic acid)” NCT00422643 ↗ |
| Known as | Hyaluronic Acid (HA) | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06865092 ↗ |
| Known as | hyaluronic acid sodium salt | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05130814 ↗ |
| Known as | HYLO COMOD eye drops | “Participants received 0.1% sodium hyaluronate eye drop (HYLO COMOD® eye drops, Ursapharm, Ltd., Germany).” NCT06696625 ↗ |
| Known as | Hylo-comod | “The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod)” NCT04711642 ↗ |
| Known as | Hylogel | “0.2 % sodium hyaluronate (Hylogel, Pharmex, Greece) quid for 6 weeks” NCT03705949 ↗ |
| Known as | Hyruan One | “(Sodium Hyaluronate (Hyruan One , LG)” NCT05861570 ↗ |
| Known as | Hyruan Plus | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01510535 ↗ |
| Known as | Hyruan Plus Inj. | “Hyruan Plus Inj. (2ml)once weekly for 3 weeks in control group” NCT01510535 ↗ |
| Known as | Intragel | “HA formulation will be Intragel (IBSA) which include 2cc with a concentration of 16mg per 2cc.” NCT02258295 ↗ |
| Known as | New Hyaluni | “the group 3 uses 0.15% sodium hyaluronate ophthalmic solution (New Hyaluni 0.15%; Taejoon, Seoul, Korea) 6 times a day.” NCT03640351 ↗ |
| Known as | Oralvisc | “The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on” PMID 24899570 ↗ Jun 2014 |
| Known as | Ostenil plus | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01288001 ↗ |
| Known as | PRO-087 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03524157 ↗ |
| Known as | Reviscon Re-Cross | “Participants will receive a single intra-articular injection of high-molecular-weight hyaluronic acid (Reviscon Re-Cross, MV Pharm; 88 mg sodium hyaluronate \[2.2%\] in 4 mL...” NCT07405840 ↗ |
| Known as | Systane ultra plus | “The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod)” NCT04711642 ↗ |
| Known as | Visco-3 | “Visco-3 (sodium hyaluronate 25 mg/2.5 mL), FDA-approved for knee osteoarthritis.” NCT07688096 ↗ |
| Modality | Other / unclassified | “Tear substitute containing hyaluronic acid, four times daily” NCT03318874 ↗ |
| Route | Other | “Injection of Healon into the anterior chamber prior to and throughout the cataract surgery procedure” NCT00763360 ↗ |
| Target | CD44 | “35 kDa B-HA induced human erythrocyte aggregation (rouleaux formation) and accelerated erythrocyte sedimentation rates through the CD44 receptor.” PMID 36686276 ↗ Jan 2023 |