Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis
Summary
The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis. The main questions it aims to answer are: * Is Hyaluronic acid injection improve pain symptom, joint stiffness, and joint function in patients with knee osteoarthritis * Is Hyaluronic acid injection improve knee performance status and health-related quality of life in patients with knee osteoarthritis Participants will be allocated to receive one treatments; either Hyaluronic acid or normal saline injections after receiving glucocorticoid injection. Researchers will compare the Hyaluronic acid with normal saline injection to see if the former show superior effect in terms of pain, joint stiffness, function, as well as health-related quality of life comparing with placebo.
Timeline
- Start
- 2024-02-10
- Primary completion
- 2025-01-31
- Completion
- 2025-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Sodium Hyaluronate | Other / unclassified | 2 ml | — |
| Comparator | Sodium Hyaluronate | Other / unclassified | 40 mg | — |
| Comparator | Triamcinolone Acetonide | Other / unclassified | 10 mg | Other |