A-PRF AND HA AFTER IMPACTED THIRD MOLAR SURGERY
Summary
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars. Participants were assigned to one of three groups: A-PRF applied to the extraction socket, HA applied to the extraction socket, or a control group receiving no additional biomaterial. Postoperative pain, facial swelling, and maximum mouth opening were assessed during the first postoperative week. Radiographic bone healing was evaluated using fractal dimension and mean gray value measurements on panoramic radiographs obtained on postoperative days 7 and 90. The study aimed to determine whether A-PRF or HA could improve postoperative clinical recovery and radiographic bone healing compared with standard treatment alone.
Timeline
- Start
- 2025-08-11
- Primary completion
- 2026-06-30
- Completion
- 2026-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Advanced Platelet-Rich Fibrin | Other / unclassified | — | Other |
| Subject | Sodium Hyaluronate | Other / unclassified | 0.8 % | Other |
| Subject | Sodium Hyaluronate | Other / unclassified | 1 ml | Other |