HA35 Moderate Alcoholic Hepatitis (AH) Study

Summary

Eligible participants will be asked to take a placebo/treatment capsule for 90 days and participate in two in-person study visits, one at the start of the 90 days and the second at the completion of study supplement administration. Both visits will include a physical exam, clinical labs, body composition measurements, muscle strength tests, questionnaires, and urine and stool collections. Additionally, a sugar cocktail will be consumed to measure gut permeability and a muscle biopsy will be collected. The day after the visits, you will need to return to drop off the 24-hour urine collection. Two phone visits will be performed in between the in-person visits at day 30 and 60 where you will be asked a series of questionnaires as well as asked about study supplement compliance.

Timeline

Start

2022-09-01

Primary completion

2026-10-01

Completion

2027-10-01

Publications

• Welch N, Kannan P, Davuluri G, Bellar A, Attaway AH, Mishra S, Cunningham JA, Kumar A, Musich R, Ertugral EG, Agrawal V, Hsu IL, Harford TJ, Weisleder NL, Vachharajani VT, Kothapalli CR, de la Motte CA, Nagy LE, Dasarathy S. Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure. Am J Physiol Endocrinol Metab. 2026 Feb 1;330(2):E212-E232. doi: 10.1152/ajpendo.00283.2025. Epub 2026 Jan 6.

Drugs

Indications