drugset / Trial / NCT04435834
Individual Cerebral Hemodynamic Oxygenation Relationships
RandomizedParallel-groupDouble-blindBasic science
Summary
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All eligible subjects will be asked to provide informed consent before participating in the study.
Timeline
- Start
- 2020-06-09
- Primary completion
- 2026-09-10
- Completion
- 2026-09-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Propofol | Small molecule | 100 ug/kg | — |
| Subject | Propofol | Small molecule | 300 ug/kg | — |
| Subject | Sevoflurane | Other / unclassified | 2.8 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 3 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 3.3 % | Inhaled |
Indications
No indication recorded.