Effect of Butorphanol on Colonoscopy for Patients With Postoperative Visceral Pain

Summary

The total incidence of abdominal pain after colonoscopy is almost 50%. Butorphanol is a mixed opioid receptor agonist-antagonist, which has strong sedative and analgesic effects. This clinical study aims to explore the effectiveness and safety of butorphanol combined with propofol for colonoscopy to reduce postoperative visceral pain, and provide a basis for improving the quality of surgery and comfortable medical treatment for patients.

Timeline

Start

2020-08-14

Primary completion

2021-09-30

Completion

2021-09-30

Outcome

Met primary endpoint

paper The incidence of visceral pain at 10 min after recovery was found to be statistically lower with butorphanol than with the placebo PMID 36977981 ↗

paper (31.5% vs. 68.5%, respectively; RR: 2.738, 95% CI [1.409-5.319], P = 0.002) PMID 36977981 ↗

Publications

• Wang J, Wang X, Liu H, Han R. Effect of butorphanol on visceral pain in patients undergoing gastrointestinal endoscopy: a randomized controlled trial. BMC Anesthesiol. 2023 Mar 28;23(1):93. doi: 10.1186/s12871-023-02053-9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Butorphanol	Other / unclassified	10 ug/kg	Intravenous

Indications

No indication recorded.