Drugs / Butorphanol
Butorphanol
also known as
Butorphanol tartrate · Butorfanol · Butorphanol tartrate civ · Butorphanol tartrate preservative free · Dolorex · LEVO-BC-2627 · LEVO-BC-2627 TARTRATE · Moradol · +5 more
Other / unclassified targets OPRK1, OPRM1 via activation
Regulatory milestones approvals, filings & regulatory actions · 4 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (3) | US (FDA) | STADOL | — | 1982-02-26 – 2009-03-13 | fda.gov ↗ |
| Approved | US (FDA) | STADOL | — | 1978-08-22 | fda.gov ↗ |
Trials 14
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials | ||||||
| Phase 2 | NCT03429179 | Mar 2018 → Feb 2019 | — | Shengjing Hospital | Completed | No outcome recorded |
| Phase 2 | NCT03810391 | Dec 2017 → Dec 2018 | — | Shengjing Hospital | Completed | No outcome recorded |
| Phase 46 trials · 1 met primary | ||||||
| Phase 4 | NCT05024799 | Jan 2022 → Dec 2024 | respiratory failure | The Affiliated Hospital of Qingdao University | Unknown | No outcome recorded |
| Phase 4 | NCT04477733 | Aug 2020 → Sep 2021 | — | Beijing Tiantan Hospital | Completed | Met primary |
| Phase 4 | NCT04315935 | Dec 2019 → Dec 2020 | pain agnosia | Jiangsu Hengrui Pharmaceutical Co., Ltd. | Unknown | No outcome recorded |
| Phase 4 | NCT00795314 | Nov 2008 → Jul 2009 | — | Nanjing Medical University | Completed | No outcome recorded |
| Phase 4 | NCT00519246 | Feb → Dec 2007 | neuropathy, painful | Nanjing Medical University | Completed | No outcome recorded |
| Phase 4 | NCT00510666 | Jan → May 2007 | — | Nanjing Medical University | Completed | No outcome recorded |
| Phase not applicable6 trials · 1 met primary | ||||||
| — | NCT06031129 | Mar → Jul 2023 | liver and intrahepatic bile duct neoplasm | Bibo Wang | Completed | No outcome recorded |
| — | NCT06524596 | Jan → Dec 2022 | — | Wuhan Children's Hospital | Completed | No outcome recorded |
| — | NCT05201560 | Jan 2022 → Jan 2023 | nosocomial infection | Shanghai Zhongshan Hospital | Unknown | No outcome recorded |
| — | NCT04490980 | Aug → Nov 2020 | — | Tongji Hospital | Unknown | No outcome recorded |
| — | NCT04295109 | Mar → Jul 2020 | adenomyosis, endometrial cancer, leiomyoma, uterine cervix neoplasm | The First Affiliated Hospital with Nanjing Medical University | Unknown | Met primary |
| — | NCT03398759 | Feb 2018 → Dec 2020 | — | RenJi Hospital | Unknown | No outcome recorded |
| Comparator or background therapy6 trials | ||||||
| Phase 4 | NCT06398834 Background | Mar 2022 → Oct 2023 | — | Second People's Hospital of Hefei City | Completed | Mixed |
| Phase 4 | NCT04436224 Comparator | Sep 2020 → Mar 2025 | — | Nanfang Hospital, Southern Medical University | Completed | No outcome recorded |
| Phase 4 | NCT03065530 Comparator | Feb → Sep 2017 | — | The First Affiliated Hospital with Nanjing Medical University | Completed | No outcome recorded |
| Phase 4 | NCT00738192 Comparator | Jul 2008 → Mar 2009 | — | Nanjing Medical University | Completed | No outcome recorded |
| — | NCT07478692 Background | Jun → Oct 2025 | — | Qing Yuan | Completed | No outcome recorded |
| — | NCT02043366 Comparator | Feb 2014 → Jun 2015 | — | Tianjin Medical University General Hospital | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 22 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Butorphanol | “This study aimed to investigate the effect of the equivalent doses of fentanyl, oxycodone, and butorphanol on bowel function in patients undergoing laparoscopic hysterectomy.” PMID 35209847 ↗ Feb 202219“Drug: butorphanol tartrate PCA: butorphanol tartrate after cesarean section.” NCT03065530 ↗ “Butorphanol tartrate 1 mg i.v.” NCT00519246 ↗ |
| Known as | Butorfanol | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Butorphanol tartrate | “Drug: butorphanol tartrate PCA: butorphanol tartrate after cesarean section.” NCT03065530 ↗3“Butorphanol tartrate 1 mg i.v.” NCT00519246 ↗ “Drug: Butorphanol tartrate” NCT00510666 ↗ “Drug: Butorphanol Tartrate” NCT00795314 ↗ |
| Known as | Butorphanol tartrate civ | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Butorphanol tartrate preservative free | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Dolorex | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | LEVO-BC-2627 | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | LEVO-BC-2627 TARTRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Moradol | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Stadol | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Stadol ns | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Stadol preservative free | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Torbugesic | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Known as | Torbutrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL33986 ↗ |
| Action | Activate | “butorphanol has both spinal analgesic and sedative functions because of predominantly central κ-receptor agonist activation” NCT02043366 ↗2“Kappa opioid receptor partial agonist” CHEMBL33986 ↗ “Mu opioid receptor partial agonist” CHEMBL33986 ↗ |
| Modality | Other / unclassified | “Butorphanol is a mixed agonist-antagonist opioid” NCT03398759 ↗ |
| Route | Intravenous | “patients received an intravenous loading dose of 10 microg kg(-1) butorphanol followed by infusion of 2 microg kg(-1) h(-1) butorphanol” PMID 19122548 ↗ Jan 2009 |
| Target | OPRK1 | “Kappa opioid receptor partial agonist” CHEMBL33986 ↗ |
| Target | OPRM1 | “Mu opioid receptor partial agonist” CHEMBL33986 ↗ |