drugset / Trial / NCT05024799

Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation

NCT05024799

Phase 4 Unknown 300 enrolled The Affiliated Hospital of Qingdao University
RandomizedParallel-groupTriple-blindTreatment

Summary

Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.

Timeline

Start
2022-01
Primary completion
2024-12
Completion
2024-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Butorphanol Other / unclassified
Subject Fentanyl Other / unclassified
Subject Propofol Small molecule
Subject dexmedetomindine Unknown

Indications