Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients

NCT02043366 ↗

Completed 180 enrolled Tianjin Medical University General Hospital

RandomizedParallel-groupDouble-blindPrevention

Summary

Purpose: To explore and compare antihyperalgesic effects of butorphanol, flurbiprofen axetil, and a combination of both received before anesthesia induction. To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose. .

Timeline

Start: 2014-02
Primary completion: 2015-06
Completion: 2015-08

Publications

Zhang L, Shu R, Zhao Q, Li Y, Yu Y, Wang G. Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial. Br J Anaesth. 2016 Oct;117(4):504-511. doi: 10.1093/bja/aew248. Epub 2016 Oct 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Butorphanol	Other / unclassified	10 ug/kg	Intravenous
Comparator	Butorphanol	Other / unclassified	20 ug/kg	Intravenous
Comparator	Remifentanil	Small molecule	0.3 ug/kg	Intravenous
Comparator	Sufentanil	Other / unclassified	0.3 ug/kg	Intravenous
Comparator	flurbiprofen axetil	Other / unclassified	0.5 mg/kg	Intravenous
Comparator	flurbiprofen axetil	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.