Esketamine and Butorphanol for Post-Lobectomy Pain

Phase 4 Completed 223 enrolled Second People's Hospital of Hefei City Tongji Hospital · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Post-thoracotomy pain syndrome (PTPS) affects respiratory function, hindering sputum clearance and ventilation, and represents a significant complication of thoracic surgery. The analgesic effect of esketamine combined with butorphanol in PTPS is still unclear, so this study focused on this aspect.

Timeline

Start: 2022-03-01
Primary completion: 2023-10-01
Completion: 2024-01-01

Publications

Wang H, Wang Z, Zhang J, Wang X, Fan B, He W, Hu X. Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial. Int J Clin Pharm. 2025 Apr;47(2):452-461. doi: 10.1007/s11096-024-01850-7. Epub 2025 Jan 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esketamine	Other / unclassified	0.3 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	1.5 mg/kg	Intravenous
Background	Butorphanol	Other / unclassified	0.15 mg/kg	—

Indications

No indication recorded.