Esketamine and Butorphanol for Post-Lobectomy Pain

Summary

Post-thoracotomy pain syndrome (PTPS) affects respiratory function, hindering sputum clearance and ventilation, and represents a significant complication of thoracic surgery. The analgesic effect of esketamine combined with butorphanol in PTPS is still unclear, so this study focused on this aspect.

Timeline

Start

2022-03-01

Primary completion

2023-10-01

Completion

2024-01-01

Outcome

Mixed primary results

paper Group BK demonstrated significantly lower VAS scores within 48 h at rest and within 24 h during coughing postoperatively (P < 0.001). PMID 39751970 ↗

paper or chronic pain incidence [(Group B, 34.1%) vs. (Group BK, 23.3%), P = 0.111] between the two groups at the three-month follow-up. PMID 39751970 ↗

Publications

• Wang H, Wang Z, Zhang J, Wang X, Fan B, He W, Hu X. Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial. Int J Clin Pharm. 2025 Apr;47(2):452-461. doi: 10.1007/s11096-024-01850-7. Epub 2025 Jan 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esketamine	Other / unclassified	0.3 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	1.5 mg/kg	Intravenous
Background	Butorphanol	Other / unclassified	0.15 mg/kg	—

Indications

No indication recorded.