Role of Sympathetic Activation in Ischemia Reperfusion Injury

Summary

This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote ischemic preconditioning. In addition it will assess whether pharmacologic inhibition of the sympathetic nervous system can ameliorate ischemia reperfusion injury induced endothelial dysfunction.

Timeline

Start

2015-07-08

Primary completion

2022-03-01

Completion

2022-03-01

Drugs

Indications