drugset / Trial / NCT04484675
Inhaled and Intravenous Milrinone in Patients With Severe Pulmonary Hypertension
RandomizedParallel-groupQuadruple-blindSupportive care
Summary
The investigator compared difference between inhaled and intravenous milirinone in patiens with severe pulmonary hypertension undergoing cardiac surgery
Timeline
- Start
- 2023-05-20
- Primary completion
- 2025-05-10
- Completion
- 2025-05-10
Publications
- Background Denault AY, Bussieres JS, Arellano R, Finegan B, Gavra P, Haddad F, Nguyen AQN, Varin F, Fortier A, Levesque S, Shi Y, Elmi-Sarabi M, Tardif JC, Perrault LP, Lambert J. A multicentre randomized-controlled trial of inhaled milrinone in high-risk cardiac surgical patients. Can J Anaesth. 2016 Oct;63(10):1140-1153. doi: 10.1007/s12630-016-0709-8. Epub 2016 Jul 28.
- Background Wang H, Gong M, Zhou B, Dai A. Comparison of inhaled and intravenous milrinone in patients with pulmonary hypertension undergoing mitral valve surgery. Adv Ther. 2009 Apr;26(4):462-8. doi: 10.1007/s12325-009-0019-4. Epub 2009 Apr 16.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Milrinone | Small molecule | 0.5 ug/kg | Inhaled |
| Comparator | Milrinone | Small molecule | 1 mg/ml | Inhaled |