Drugs / Milrinone
last change Jun 2026 re-read 2 minutes ago

Milrinone

Small molecule targets PDE3A via inhibition

Developed for
heart failure · congenital heart disease · pulmonary hypertension · pulmonary hypertension, neonatal · acquired aneurysmal subarachnoid hemorrhage · advanced heart failure · aortic valve stenosis · cardiogenic shock
+10 more · cardiomyopathy · congenital diaphragmatic hernia · diastolic heart failure · infectious disease with sepsis · intracranial vasospasm · mitral valve insufficiency · persistent fetal circulation syndrome · cardio-renal syndrome · myocardial infarction · postoperative ventricular dysfunction
Investigated by
Sahlgrenska University Hospital · American Medical Association · Bedford Pharmaceuticals · Canadian Institutes of Health Research (CIHR) · Children's Hospital of Philadelphia · Cliniques universitaires Saint-Luc- Université Catholique de Louvain
+21 more · Deutsche Stiftung für Herzforschung · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Fonds de la Recherche en Santé du Québec · Konkuk University Medical Center · Mahidol University · Montreal Heart Institute · Muhammad Aamir Latif · NICHD Neonatal Research Network · Shanghai Children's Medical Center · St. Justine's Hospital · The Alfred · The Hospital for Sick Children · Thoratec Corporation · Thrasher Research Fund · University Hospital, Angers · University Hospital, Toulouse · University of Kansas Medical Center · University of Luebeck · University of Nebraska · University of Pennsylvania · Vanderbilt University Medical Center

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02077010 Jun 2020 → Jan 2023 cardiomyopathy, heart failure University of Kansas Medical Center Completed No outcome recorded
Phase 1 NCT01571037 Apr 2012 → Feb 2013 advanced heart failure University of Nebraska Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01956006 Oct 2013 → May 2017 heart failure The Alfred Completed No outcome recorded
Phase 25 trials
Phase 2 NCT05122884 Dec 2021 → Dec 2024 infectious disease with sepsis Mahidol University Unknown No outcome recorded
Phase 2 NCT04282629 Jul 2021 → Jul 2025 overdue acquired aneurysmal subarachnoid hemorrhage University Hospital, Toulouse Recruiting No outcome recorded
Phase 2 NCT02951130 Oct 2017 → Sep 2024 congenital diaphragmatic hernia, pulmonary hypertension, neonatal, pulmonary hypoplasia, respiratory failure NICHD Neonatal Research Network Completed No outcome recorded
Phase 2 NCT01841177 Apr 2013 → Aug 2020 congenital heart disease The Hospital for Sick Children Completed No outcome recorded
Phase 2 NCT01725776 Dec 2006 → Feb 2012 pulmonary hypertension Montreal Heart Institute Completed No outcome recorded
Phase 34 trials
Phase 3 NCT04362527 Aug 2020 → Oct 2025 intracranial vasospasm University Hospital, Angers Completed No outcome recorded
Phase 3 NCT03823781 Feb 2019 → Jan 2021 Shanghai Children's Medical Center Unknown No outcome recorded
Phase 3 NCT00446017 Jun 2003 → Aug 2004 heart failure University of Luebeck Completed No outcome recorded
Phase 3 NCT01621971 Jan 2003 → Jan 2004 mitral valve insufficiency, pulmonary hypertension Konkuk University Medical Center Completed No outcome recorded
Phase not applicable5 trials
NCT06562036 Dec 2023 → May 2024 pulmonary hypertension, neonatal Muhammad Aamir Latif Completed No outcome recorded
NCT02549066 Jan 2016 → Jun 2017 impaired renal function disease Sahlgrenska University Hospital Completed No outcome recorded
NCT02408003 Mar 2014 → May 2016 aortic valve stenosis, diastolic heart failure Sahlgrenska University Hospital Completed No outcome recorded
NCT01088997 Jun 2010 → Feb 2013 persistent fetal circulation syndrome Children's Hospital of Philadelphia Terminated No outcome recorded
NCT00695929 Jul 2008 → Sep 2009 cardiogenic shock, congenital heart disease Cliniques universitaires Saint-Luc- Université Catholique de Louvain Completed No outcome recorded
Also used as a comparator or background therapy in 33 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05700617 Comparator Jul 2023 → Jun 2026 overdue cardiogenic shock, heart failure University of Chicago Recruiting No outcome recorded
Phase 11 trial
Phase 1 NCT04391478 Comparator Jan → Apr 2015 pulmonary hypertension, neonatal Rania Ali El-Farrash Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT03180450 Background Dec 2025 → Jun 2026 heart failure Sclnow Biotechnology Co., Ltd. Suspended No outcome recorded
Phase 1/2 NCT02595541 Comparator Jun → Oct 2015 pulmonary hypertension Assiut University Completed No outcome recorded
Phase 1/2 NCT01849094 Comparator May 2013 → Dec 2014 heart failure The Alfred Completed No outcome recorded
Phase 1/2 NCT01576094 Comparator Nov 2009 → Nov 2010 Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz Completed No outcome recorded
Phase 211 trials
Phase 2 NCT05450328 Comparator Dec 2025 → May 2028 expected heart failure, postoperative ventricular dysfunction Montreal Heart Institute Recruiting No outcome recorded
Phase 2 NCT05131867 Comparator Nov 2021 → May 2022 intracranial vasospasm Zagazig University Completed No outcome recorded
Phase 2 NCT02712788 Comparator Apr 2016 → Oct 2017 intracranial vasospasm Indiana University Terminated No outcome recorded
Phase 2 NCT02644057 Comparator Mar → Sep 2016 cardio-renal syndrome Maimonides Medical Center Withdrawn No outcome recorded
Phase 2 NCT02098629 Comparator May 2015 → Mar 2023 myocardial infarction Shantou University Medical College Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT05838846 Comparator Apr 2023 → Jan 2025 pulmonary hypertension Menoufia University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT06679855 Comparator Jun 2025 → Jun 2027 expected NICHD Neonatal Research Network Recruiting No outcome recorded
Phase 3 NCT06301880 Comparator Jan 2022 → Jan 2023 Damascus University Completed No outcome recorded
Phase 46 trials
Phase 4 NCT04484675 Comparator May 2023 → May 2025 overdue pulmonary hypertension Zagazig University Recruiting No outcome recorded
Phase 4 NCT05267886 Comparator Mar 2022 → Dec 2026 expected cardiogenic shock Ottawa Heart Institute Research Corporation Recruiting No outcome recorded
Phase 4 NCT05132153 Comparator Oct 2021 → Sep 2022 Ain Shams University Unknown No outcome recorded
Phase 4 NCT03855579 Comparator Mar → Sep 2019 Assiut University Unknown No outcome recorded
Phase 4 NCT03207165 Comparator Aug 2017 → Jun 2020 acute coronary syndrome, cardiogenic shock, pulmonary edema Ottawa Heart Institute Research Corporation Completed No outcome recorded
Phase not applicable7 trials
NCT07144267 Comparator Mar 2026 → Dec 2027 expected Mansoura University Not yet recruiting No outcome recorded
NCT05064202 Background Oct 2023 → Oct 2027 expected cardiogenic shock Amsterdam UMC, location VUmc Not yet recruiting No outcome recorded
NCT04792424 Background Apr 2021 → May 2022 Chulalongkorn University Completed No outcome recorded
NCT04718350 Comparator Jan 2021 → Dec 2023 heart failure, pulmonary hypertension Aretaieion University Hospital Completed No outcome recorded
NCT02726620 Background Jan → Dec 2017 hypotensive disorder Vanderbilt University Medical Center Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 52 sources stand behind the page.

FieldValueCited text
Known as Milrinone milrinone (Baxter Pharmaceuticals, Ahmedabad, India) 10 mg in 20 ml of dextrose 5%, nitroglycerin (Caspian Tamin Pharmaceutical, Guilan, Iran) 10 mg in 20 ml of normal saline,...” NCT06301880
49

“including milrinone, furosemide, beta-blocker blues, Angiotensin-Converting Enzyme Inhibitors (ACEI), angiotension receptor blocker (ARB), or antiplatelet aggregation etc.” NCT03180450

“Vasopressors such as Norepinephrine, dopamine, milrinone, dobutamine” NCT02730117

“Vasopressors such as Norepinephrine, dopamine, milrinone, dobutamine” NCT04792424

“dopamine and / or dobutamine and / or milrinone and / or adrenaline” NCT01301313

“Enoximone, Dobutamine, Dopamine, MilrinoneNCT05064202

NCT05838846

NCT04718350

NCT00966745

NCT00338455

NCT02077010

NCT03823781

NCT02232399

NCT01849094

NCT02644057

NCT02726620

NCT02640846

NCT01088997

NCT03207165

NCT05131867

NCT01725776

NCT01571037

NCT06679855

NCT05267886

NCT04391478

NCT06562036

NCT01956006

NCT04282629

NCT01841177

NCT07144267

NCT05132153

NCT03855579

NCT02712788

NCT05700617

NCT02098629

NCT00819377

NCT00543309

NCT05122884

NCT04484675

NCT02595541

NCT00695929

NCT02408003

NCT01576094

NCT05450328

NCT00446017

NCT02549066

NCT04362527

NCT02951130

NCT00549107

NCT01621971

Known as Milrila ChEMBL registry synonym — accepted as the source's own label CHEMBL189
Known as Milrinona ChEMBL registry synonym — accepted as the source's own label CHEMBL189
Known as milrinone lactate milrinone lactate, 1mg/ml, for intra venous use only” NCT04391478
Known as NSC-760072 ChEMBL registry synonym — accepted as the source's own label CHEMBL189
Known as Primacor ChEMBL registry synonym — accepted as the source's own label CHEMBL189
Known as WIN 47,203-2 ChEMBL registry synonym — accepted as the source's own label CHEMBL189
Action Inhibit “This suggests that the use of adrenaline for the treatment of postoperative myocardial dysfunction - in contrast to treatment with the PDE-III inhibitor milrinone - is...” PMID 17470271 2007
1

“Phosphodiesterase 3A inhibitor” CHEMBL189

Modality Small molecule CHEMBL189
Route Intravenous “continuous intravenous infusion of dobutamine or milrinone” NCT00338455
Target PDE3A “Phosphodiesterase 3A inhibitor” CHEMBL189