drugset / Trial / NCT06562036

Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children

NCT06562036

Completed 42 enrolled Muhammad Aamir Latif
RandomizedParallel-groupOpen-labelTreatment

Summary

Neonates with persistent pulmonary hypertension (PPH) should be administered inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO), but these are not available in most resource-constrained settings like ours. This study was planned to compare the outcomes of Milrinone plus Sildenafil versus Sildenafil alone in the treatment of PPH in neonates.

Timeline

Start
2023-12-01
Primary completion
2024-05-31
Completion
2024-05-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Milrinone Small molecule 0.5 ug/kg Intravenous
Subject Sildenafil Unknown 2 mg/kg Oral