drugset / Trial / NCT06562036
Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children
RandomizedParallel-groupOpen-labelTreatment
Summary
Neonates with persistent pulmonary hypertension (PPH) should be administered inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO), but these are not available in most resource-constrained settings like ours. This study was planned to compare the outcomes of Milrinone plus Sildenafil versus Sildenafil alone in the treatment of PPH in neonates.
Timeline
- Start
- 2023-12-01
- Primary completion
- 2024-05-31
- Completion
- 2024-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Milrinone | Small molecule | 0.5 ug/kg | Intravenous |
| Subject | Sildenafil | Unknown | 2 mg/kg | Oral |