A Drug-drug Interaction Trial to Evaluate the Pharmacokinetics Effect of Rifampicin on Famitinib

Phase 1 Completed 21 enrolled Jiangsu HengRui Medicine Co., Ltd.

NaSingle-groupOpen-labelBasic science

Summary

The primary objective of the study was to assess the effect of repeated oral doses of Rifampicin on the pharmacokinetic profile of a single dose of Famitinib. The secondary objective of the study was to assess the safety of Famitinib given alone versus Famitinib co-administered with Rifampicin.

Timeline

Start: 2020-07-20
Primary completion: 2020-08-13
Completion: 2020-08-31

Publications

Li T, Li X, Jiang X, Wang C, Sun F, Liu Y, Lin P, Shi P, Fu Y, Gao X, Zhang Y, Cao Y. The effect of rifampin on the pharmacokinetics of famitinib in healthy subjects. Cancer Chemother Pharmacol. 2022 Nov;90(5):409-415. doi: 10.1007/s00280-022-04474-8. Epub 2022 Sep 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Famitinib	Small molecule	25 mg	Oral
Subject	Rifampin	Small molecule	600 mg	Oral

Indications

No indication recorded.