Drugs / Famitinib
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Famitinib

Small molecule targets FLT1, FLT3, FLT4, KDR, KIT, PDGFRA via inhibition

Developed for
non-small cell lung carcinoma · triple-negative breast carcinoma · breast cancer · cervical cancer · neoplasm · cancer · nasopharyngeal carcinoma · female breast carcinoma
+26 more · gastrointestinal stromal tumor · hormone receptor-positive breast cancer · intrahepatic cholangiocarcinoma · melanoma · ovarian cancer · renal cell carcinoma · small cell lung carcinoma · thyroid cancer · breast neoplasm · colorectal cancer · digestive system neuroendocrine neoplasm · endometrial cancer · esophageal squamous cell carcinoma · estrogen-receptor positive breast cancer · gastric neoplasm · head and neck cancer · Her2-receptor negative breast cancer · lung cancer · lung sarcomatoid carcinoma · malignant pancreatic neoplasm · metastasis from malignant tumor of colon · metastatic malignant neoplasm · neoplastic disease or syndrome · ovarian carcinoma · pediatric osteosarcoma · urothelial carcinoma
Investigated by
Jiangsu HengRui Medicine Co., Ltd. · Fudan University · Sun Yat-sen University · Peking University Cancer Hospital & Institute · Shanghai Pulmonary Hospital, Shanghai, China · Tianjin Medical University Cancer Institute and Hospital
+33 more · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Affiliated Hospital of Nantong University · Baohui Han · Chinese Academy of Medical Sciences · Chinese Academy of Sciences · Chongqing University Cancer Hospital · First Affiliated Hospital Xi'an Jiaotong University · First Hospital of China Medical University · Fujian Medical University Union Hospital · Harbin Medical University · Henan Cancer Hospital · Hunan Cancer Hospital · Jiangsu Hengrui Pharmaceutical Co., Ltd. · Jiangsu Province Nanjing Brain Hospital · Jinhua Zhou · Liaoning Cancer Hospital & Institute · Nanchang People's Hospital · Ningbo Medical Center Lihuili Hospital · Northern Jiangsu People's Hospital · Peking University People's Hospital · Peking University Shougang Hospital · Qian Chu · Qinglei Gao · Ruijin Hospital · Second Affiliated Hospital of Xi'an Jiaotong University · Shandong Tumor Hospital · Shanghai 6th People's Hospital · Shanghai Chest Hospital · Shanghai First Maternity and Infant Hospital · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai Zhongshan Hospital · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · The First Hospital of Jilin University

Trials 70 · started per year

today
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20092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT05473468 Aug → Nov 2022 Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1 NCT05147727 Mar → May 2022 neoplasm Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05103826 Oct 2021 → Jun 2023 estrogen-receptor positive breast cancer Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 1 NCT05046808 Sep → Oct 2021 cancer Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05041920 Sep → Oct 2021 neoplasm Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04494659 Jul → Aug 2020 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT02364362 Jan 2015 → Dec 2018 non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT01462474 Oct 2011 → Aug 2015 nasopharyngeal carcinoma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT01762280 Jun 2009 → Apr 2012 neoplasm Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT07662681 Jul 2026 → Jul 2028 expected head and neck cancer Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Recruiting No outcome recorded
Phase 1/2 NCT06332950 Apr 2024 → Apr 2027 expected small cell lung carcinoma Baohui Han Not yet recruiting No outcome recorded
Phase 1/2 NCT05176080 Dec 2021 → Jul 2024 breast cancer Henan Cancer Hospital Terminated No outcome recorded
Phase 1/2 NCT05020925 Sep 2021 → May 2022 nasopharyngeal carcinoma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT04679038 Mar 2021 → Dec 2022 cancer Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT04044378 Aug 2019 → Sep 2021 pediatric osteosarcoma Peking University People's Hospital Withdrawn No outcome recorded
Phase 1/2 NCT03805399 Oct 2018 → Dec 2022 triple-negative breast carcinoma Fudan University Unknown No outcome recorded
Phase 243 trials
Phase 2 NCT07627620 Jun 2026 → Sep 2027 expected cervical cancer Hunan Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07517653 Apr 2026 → Nov 2028 expected melanoma Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07382713 Feb 2026 → Dec 2030 expected ovarian cancer Jinhua Zhou Not yet recruiting No outcome recorded
Phase 2 NCT07355010 Dec 2025 → Dec 2028 expected ovarian cancer Qinglei Gao Not yet recruiting No outcome recorded
Phase 2 NCT07143292 Nov 2025 → Dec 2026 expected cervical cancer Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Not yet recruiting No outcome recorded
Phase 2 NCT07147088 Sep 2025 → Sep 2027 expected intrahepatic cholangiocarcinoma Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06649331 Oct 2024 → Sep 2026 expected triple-negative breast carcinoma Fudan University Recruiting No outcome recorded
Phase 2 NCT06516289 Sep 2024 → Jun 2026 overdue Her2-receptor negative breast cancer Fudan University Recruiting No outcome recorded
Phase 2 NCT07309185 Jul 2024 → Jul 2027 expected gastric neoplasm Shandong Tumor Hospital Recruiting No outcome recorded
Phase 2 NCT06336954 Mar → Jul 2024 overdue non-small cell lung carcinoma Second Affiliated Hospital of Xi'an Jiaotong University Not yet recruiting No outcome recorded
Phase 311 trials
Phase 3 NCT07382687 Feb 2026 → Dec 2028 expected breast cancer Fudan University Not yet recruiting No outcome recorded
Phase 3 NCT06913777 Apr 2025 → Oct 2026 expected Fudan University Recruiting No outcome recorded
Phase 3 NCT05999149 Aug 2023 → Aug 2025 overdue triple-negative breast carcinoma Fudan University Recruiting No outcome recorded
Phase 3 NCT05760378 Mar 2023 → Jan 2025 overdue triple-negative breast carcinoma Fudan University Recruiting No outcome recorded
Phase 3 NCT05042375 Sep 2022 → Dec 2023 non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 3 NCT05106335 Jan → May 2022 non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 3 NCT04906993 Jul 2021 → Jun 2025 overdue cervical cancer Jiangsu HengRui Medicine Co., Ltd. Active not recruiting No outcome recorded
Phase 3 NCT04619433 Feb 2021 → Aug 2025 non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 3 NCT04409223 Sep 2020 → Mar 2022 gastrointestinal stromal tumor Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded
Phase 3 NCT02766140 Jun → Nov 2016 non-small cell lung carcinoma Jiangsu HengRui Medicine Co., Ltd. Terminated No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 73 sources stand behind the page.

FieldValueCited text
Known as Famitinib “Adibelimab (1200mg, IV, every 3 weeks) combined with Famitinib (20mg, daily, orally) and Albumin-bound Paclitaxel (260mg/m2, Day 1, every 3 weeks)” NCT06336954
64

famitinib plus anti-PD-1 antibody could advance TLS in thyroid cancer.” PMID 38478516 Mar 2024

“and famitinib 20mg qd continuously” NCT03805399

NCT05208177

NCT04906993

NCT01462474

NCT05020925

NCT07309185

NCT07147088

NCT07382713

NCT05214976

NCT07517653

NCT04346381

NCT04733417

NCT02336724

NCT05999149

NCT05749588

NCT05103826

NCT04129996

NCT01994213

NCT05106335

NCT04044378

NCT06649331

NCT05473468

NCT06913777

NCT07382687

NCT05176080

NCT04479904

NCT05005468

NCT02356991

NCT05670925

NCT05041920

NCT06306560

NCT03827837

NCT03904823

NCT07662681

NCT01762280

NCT01392235

NCT04619433

NCT07143292

NCT04679038

NCT05042375

NCT01762293

NCT06516289

NCT05760378

NCT04699968

NCT02364362

NCT04884009

NCT05594095

NCT04355858

NCT07355010

NCT06146985

NCT06332300

NCT07627620

NCT02390947

NCT04395989

NCT04494659

NCT01829841

NCT05582499

NCT05046808

NCT04409223

NCT05147727

NCT06332950

NCT01653574

NCT04888429

Known as C1: PD-1 with nab-paclitaxel and famitinib ClinicalTrials.gov intervention name — accepted as the source's own label NCT04395989
Known as Famitinib Malate Famitinib Malate Capsules 10mg single dose” NCT05046808
3

famitinib malate, 25 mg on study day 1” NCT05041920

Famitinib malate capsules, 20 mg” NCT05042375

Famitinib malate capsules, qd.” NCT05208177

Known as SHR1020 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02766140
4

NCT04814485

NCT04866381

NCT04680988

NCT05051865

Action Inhibit “tyrosin-inhibitor agent targeting at c-Kit, VEGFR2, PDGFR, VEGFR3, Flt1 and Flt3” NCT01392235
1

“Vascular endothelial growth factor receptor 3 inhibitor” CHEMBL1278146

Modality Small molecule “Famitinib is a small-molecule multikinase inhibitor” PMID 29273089 Dec 2017
Route Oral “25 mg qd p.o.” NCT01392235
Target FLT4 “Vascular endothelial growth factor receptor 3 inhibitor” CHEMBL1278146
Target KDR “Famitinib is an inhibitor of multiple tyrosine kinases mainly targeting VEGFR-2.” PMID 24939214 Jun 2014