drugset / Trial / NCT07143292
A Prospective, Randomized, Parallel Trial of Famitinib Malate at Different Doses Combined With Camrelizumab for the Treatment of Recurrent and Metastatic Cervical Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
This study is a prospective, randomized, parallel investigation aimed at evaluating different doses of famitinib malate (20mg, 15mg, or 10mg, once daily, respectively) by analyzing the pharmacokinetics, efficacy, safety, and tolerability of famitinib malate combined with camrelizumab at different doses. The feasibility of continuously oral administration combined with camrelizumab in reducing the incidence of adverse events (especially grade ≥3 adverse events) in patients by dose reduction while maintaining comparable efficacy.
Timeline
- Start
- 2025-11-30
- Primary completion
- 2026-12-30
- Completion
- 2028-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Famitinib | Small molecule | 10 mg | Oral |
| Subject | Famitinib | Small molecule | 15 mg | Oral |
| Subject | Famitinib | Small molecule | 20 mg | Oral |
| Background | Camrelizumab | Monoclonal antibody | 200 mg | Intravenous |