drugset / Trial / NCT07143292

A Prospective, Randomized, Parallel Trial of Famitinib Malate at Different Doses Combined With Camrelizumab for the Treatment of Recurrent and Metastatic Cervical Cancer

NCT07143292

Phase 2 Not yet recruiting 120 enrolled Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
RandomizedParallel-groupOpen-labelTreatment

Summary

This study is a prospective, randomized, parallel investigation aimed at evaluating different doses of famitinib malate (20mg, 15mg, or 10mg, once daily, respectively) by analyzing the pharmacokinetics, efficacy, safety, and tolerability of famitinib malate combined with camrelizumab at different doses. The feasibility of continuously oral administration combined with camrelizumab in reducing the incidence of adverse events (especially grade ≥3 adverse events) in patients by dose reduction while maintaining comparable efficacy.

Timeline

Start
2025-11-30
Primary completion
2026-12-30
Completion
2028-06-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Famitinib Small molecule 10 mg Oral
Subject Famitinib Small molecule 15 mg Oral
Subject Famitinib Small molecule 20 mg Oral
Background Camrelizumab Monoclonal antibody 200 mg Intravenous

Indications