drugset / Trial / NCT04502589
Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
Phase 1/2
Completed
4 enrolled
Virginia Commonwealth University
National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this research study is to test the safety, tolerability, and effectiveness of the drug Perampanel when used in persons who drink and wish to stop drinking. Perampanel has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of seizures but has not yet been approved to treat alcohol use disorders. For this reason, it is considered an investigational drug. Some people in this study will receive Perampanel alone and some people will receive Perampanel and Disulfiram, this will be determined by the pharmacy.
Timeline
- Start
- 2020-10-15
- Primary completion
- 2021-08-11
- Completion
- 2021-08-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Disulfiram | Small molecule | 250 mg | — |
| Comparator | Perampanel | Small molecule | 8 mg | — |