INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study

Summary

The central hypothesis is that inflammation mediators are biomarkers of both systemic diabetes and Diabetic Retinopathy (DR) progression in the aqueous and that sustained topical ketorolac application reduces/suppresses those inflammatory mediators thereby reducing the progression of Diabetic Retinopathy.

Timeline

Start

2020-11-09

Primary completion

2026-04-21

Completion

2026-04-21

Publications

• Kim SJ, Gangaputra S, Sheng J, Patel S, Nair AA, Al Hussein Al Awamlh S, Fitzpatrick J, Cherney E, Veach L, Nicholson C. Analysis of 24 pro-inflammatory cytokines in aqueous and serum of 94 patients without diabetes. Br J Ophthalmol. 2025 Nov 20;109(12):1357-1362. doi: 10.1136/bjo-2025-327421.

Drugs

Indications