Metabolic Effects of Metformin Therapy in Obstructive Sleep Apnea

Phase 1/2 Terminated 16 enrolled Pennington Biomedical Research Center National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The purpose of the study is to see if metformin improves metabolism in patients with obstructive sleep apnea (OSA) using positive airway pressure (PAP) therapy. Metformin is approved by the Food and Drug Administration (FDA) for the treatment and prevention of diabetes. It is not approved for use in patients with OSA.

Timeline

Start: 2021-01-28
Primary completion: 2021-11-30
Completion: 2021-11-30

Publications

Zunica ERM, Heintz EC, Dantas WS, Hebert RC, Tanksley M, Beyl RA, Mader EC Jr, Kirwan JP, Axelrod CL, Singh P. Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial. Physiol Rep. 2024 Feb;12(3):e15948. doi: 10.14814/phy2.15948.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	2000 mg	Oral

Metabolic Effects of Metformin Therapy in Obstructive Sleep Apnea

Summary

Timeline

Publications

Drugs

Indications