drugset / Trial / NCT04543370
Study of Edasalonexent With Midazolam and Deflazacort in Healthy Subjects
Non-randomizedSingle-groupOpen-labelHealth-services research
Summary
Drug-drug interaction (DDI) and Cardiodynamic Evaluation Study To assess the effect of multiple oral doses of edasalonexent on the single-dose pharmacokinetics (PK) of midazolam (a cytochrome P450 \[CYP\]3A4 sensitive substrate) and of deflazacort (a CYP3A4 moderate sensitive substrate) in healthy adult subjects.
Timeline
- Start
- 2020-08-08
- Primary completion
- 2020-09-06
- Completion
- 2020-10-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Deflazacort | Other / unclassified | 36 mg | — |
| Subject | Edasalonexent | Small molecule | 2000 mg | Oral |
| Subject | Midazolam | Small molecule | 2 mg | — |
Indications
No indication recorded.