drugset / Trial / NCT04543643

Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis

NCT04543643

Phase 3 Unknown 288 enrolled Tianjin Second People's Hospital
RandomizedParallel-groupOpen-labelPrevention

Summary

Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. A lot of studies have shown that the imbalance of flora and the progress of portal hypertension are mutually causal. Berberine can regulate the intestinal flora.In this study, we evaluated the effect of carvedilol and berberine on reducing portal vein pressure by observing the changes of endoscopy,endoscopic ultrasonography and intestinal flora.

Timeline

Start
2021-11-01
Primary completion
2023-10-31
Completion
2023-10-31

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Berberine Traditional medicine (herbal / TCM) 0.3 g
Subject Carvedilol Other / unclassified 6.25 mg