drugset / Trial / NCT04543643
Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis
RandomizedParallel-groupOpen-labelPrevention
Summary
Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. A lot of studies have shown that the imbalance of flora and the progress of portal hypertension are mutually causal. Berberine can regulate the intestinal flora.In this study, we evaluated the effect of carvedilol and berberine on reducing portal vein pressure by observing the changes of endoscopy,endoscopic ultrasonography and intestinal flora.
Timeline
- Start
- 2021-11-01
- Primary completion
- 2023-10-31
- Completion
- 2023-10-31
Publications
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Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Berberine | Traditional medicine (herbal / TCM) | 0.3 g | — |
| Subject | Carvedilol | Other / unclassified | 6.25 mg | — |