Berberine
Traditional medicine (herbal / TCM) targets KCNH6, LDLR via inhibition
Trials 56
Evidence & citations 27 cited values
Every value below carries the sentence it was read from. 66 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Berberine | “Berberine
* Dose: 500 mg three times daily (1,500 mg/day total)
* Formulation: standardized berberine HCl tablets
* Duration: 12 weeks” NCT06911983 ↗54“nutraceutical combined pill (1 capsule/day containing red yeast rice 200 mg, policosanol 10 mg, and berberine 500 mg).” NCT02001883 ↗ “os, 1 pill containing red yeast rice 200 mg, policosanol 10 mg, and berberine 500 mg, once daily, 1 year” NCT01490229 ↗ “1 capsule/day containing red yeast rice 200 mg, policosanol 10 mg, and berberine 500 mg” NCT01649986 ↗ “oral administration of berberine hydrochloride tablets 100mg Tid per day” NCT07180563 ↗ |
| Known as | BBR | “This study is designed as a large-scale, randomized, placebo-controlled, rater-blinded trial to investigate whether berberine (BBR), a chemical compound, can safely and...” NCT07356765 ↗8“Our previous clinical trial demonstrated that berberine (BBR) hydrochloride might reduce the recurrence and canceration of colorectal adenoma (CRA).” PMID 37553874 ↗ Aug 2023 “Berberine (BBR) hydrochloride is an isoquinoline alkaloid (chemical formula: C20H18NO4) extracted from traditional Chinese herb Coptis chinensis.” NCT04790942 ↗ “Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis.” PMID 33024120 ↗ Oct 2020 “Berberine (BBR), a small alkaloid isolated from medicinal plants, has antidiabetic, anti-inflammatory, and antibacterial effects.” PMID 35784546 ↗ Jun 2022 “Berberine (BBR), an isoquinoline alkaloid derived from plants, is widely used as a nonprescription drug to treat diarrhea.” NCT03909763 ↗ “Here, we report the effects of its main active component, berberine (BBR), on stimulating insulin secretion.” PMID 34556670 ↗ Sep 2021 “Berberine (BBR) is the main active ingredient of the ancient Chinese herb medicine Coptis.” NCT05947370 ↗ “a botanic compound berberine (BBR) on NAFLD” PMID 26252777 ↗ Aug 2015 |
| Known as | Berbericine | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberin | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberine Chloride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02365480 ↗ |
| Known as | berberine hydrochloride | “berberine hydrochloride tablets (0.1g\*100 tablets/bottle, Shenyang First Pharmaceutical Co., Ltd., Northeast Pharmaceutical Group)” NCT07180563 ↗7“Patients in the berberine group received berberine hydrochloride tablets (100 mg/tablet), three tablets three times daily.” NCT07359209 ↗ “Berberine hydrochloride is a conventional component in Chinese medicine.” NCT02226185 ↗ “Drug: Berberine Hydrochloride group” NCT03330184 ↗ |
| Known as | Berberine hydrochloride tablet ("Sine Tianping") | “Berberine hydrochloride tablet ("Sine Tianping")” NCT03281096 ↗ |
| Known as | BERBERINE SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberine sulfate (2:1) | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberine sulfate anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberine sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberinum | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Berberone | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Erben | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | GNF-Pf-4545 | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Majarine | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Neutral berberine sulfate | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | NSC-163088 | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | NSC-5355 | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | NSC-646666 | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Thalsine | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Umbellatin | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Known as | Umbellatine | ChEMBL registry synonym — accepted as the source's own label CHEMBL295124 ↗ |
| Action | Inhibit | “BBR might inhibit V. parvula and further weaken the immunomodulatory effect of B cells induced by V. parvula, thereby blocking the development of colorectal tumors.” PMID 37553874 ↗ Aug 2023 |
| Modality | Traditional medicine (herbal / TCM) | “Berberine is the main active component of Coptis chinensis French, which was used for thousands of years in China in the treatment of human diseases including diabetes.” NCT00425009 ↗ |
| Route | Oral | “berberine tablet 0.5g tid,30 minutes before each meal,for 16 weeks” NCT00633282 ↗ |
| Target | LDLR | “BBR elevates LDL receptor(LDLR) expression through a post-transcriptional mechanism that stabilizes the LDLR-mRNA.” NCT00633282 ↗ |