drugset
drugset / Trial / NCT04547842

Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting

NCT04547842 ↗

Phase 0 Completed 90 enrolled Ain Shams University
RandomizedParallel-groupQuadruple-blindPrevention

Summary

Mirtazapine is a noradrenergic and specific serotonergic antidepressant. Its antagonist at the 5HT3 receptor may help to prevent nausea and vomiting. The use of mirtazapine in the management of nausea and vomiting has been reported in the literature, both for treatment and premedication. Dexamethasone, possesses analgesic, anti-inflammatory, immune-modulating, and antiemetic effects. Dexamethasone was reported to be effective in preventing nausea and vomiting in patients receiving cancer chemotherapy. It has also been shown to be effective in reducing nausea and vomiting after open and laparoscopic surgical procedures. In this randomized controlled trial, we will compare the effectiveness of both drugs in preventing PONV in laparoscopic cholecystectomy surgery.

Timeline

Start
2020-09-01
Primary completion
2023-07-28
Completion
2023-07-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexamethasone Small molecule 8 mg Intravenous
Comparator Mirtazapine Other / unclassified 30 mg Oral

Indications

No indication recorded.