drugset / Trial / NCT04556760
Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes
RandomizedCrossoverDouble-blindTreatment
Summary
The study is intended to assess the effect on glycaemic control of AZD9567, as measured by the glucose AUC(0-4) versus baseline following a standardised mixed meal tolerance test (MMTT), compared to prednisolone in adults with type 2 diabetes mellitus (T2DM). The study will also evaluate the safety, tolerability, and pharmacokinetics (PK) of AZD9567.
Timeline
- Start
- 2020-11-26
- Primary completion
- 2021-06-09
- Completion
- 2021-06-09
Outcome
Mixed primary results
registry analysis (other test); Cohort 1; p = 0.036; Mean Difference (Final Values) -132.9528 (95% CI -256.5082 to -9.3973); Mixed Models Analysis NCT04556760 ↗
registry analysis (other test); Cohort 2; p = 0.432; Mean Difference (Final Values) -142.0330 (95% CI -554.8722 to 270.8061); Mixed Models Analysis NCT04556760 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | MIZACORAT | Small molecule | 40 mg | Oral |
| Subject | MIZACORAT | Small molecule | 72 mg | Oral |
| Subject | Prednisolone | Other / unclassified | 5 mg | — |
| Subject | Prednisolone | Other / unclassified | 20 mg | — |
| Subject | Prednisolone | Other / unclassified | 40 mg | — |