drugset / Trial / NCT04566250
Non-Opioid Prescriptions After Arthroscopic Surgery in Canada (NO PAin)
Completed
200 enrolled
McMaster University
Hamilton Health Sciences Corporation · collabThe Physicians' Services Incorporated Foundation · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
This is a randomized controlled trial of 200 patients between the ages of 18 and 65 years undergoing outpatient knee or shoulder arthroscopy. Patients will be evaluated clinically at 2 and 6 weeks post-operatively. Patients will be recruited from experienced arthroscopic surgeons at 3 hospital sites in Hamilton, Ontario. All research will be conducted according to international standards of Good Clinical Practice and institutional research policies and procedures.
Timeline
- Start
- 2021-02-24
- Primary completion
- 2022-04-01
- Completion
- 2022-04-01
Publications
- NO PAin Investigators; Gazendam A, Ekhtiari S, Horner NS, Simunovic N, Khan M, de Sa DL, Madden K, Ayeni OR. Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial. JAMA. 2022 Oct 4;328(13):1326-1335. doi: 10.1001/jama.2022.16844.
- NO PAin Investigators. Protocol for a multicenter randomized controlled trial comparing a non-opioid prescription to the standard of care for pain control following arthroscopic knee and shoulder surgery. BMC Musculoskelet Disord. 2021 May 22;22(1):471. doi: 10.1186/s12891-021-04354-x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 1000 mg | Oral |
| Subject | Hydromorphone | Other / unclassified | 1 mg | Oral |
| Subject | Naproxen | Small molecule | 500 mg | Oral |
| Background | Pantoprazole | Other / unclassified | 40 mg | Oral |
Indications
No indication recorded.