Methods to Reduce Blood Loss in Abdominal Myomectomy

Summary

The aim of the study is to compare the effectiveness of a single preoperative dose of vaginal misoprostol, intraoperative oxytocin infusion, IV carbetocin and pericervical tourniquet for the reduction of blood loss during of abdominal myomectomy.

Timeline

Start

2020-11-01

Primary completion

2022-08-31

Completion

2022-09-15

Publications

• Background Abdel-Hafeez M, Elnaggar A, Ali M, Ismail AM, Yacoub M. Rectal misoprostol for myomectomy: A randomised placebo-controlled study. Aust N Z J Obstet Gynaecol. 2015 Aug;55(4):363-8. doi: 10.1111/ajo.12359. Epub 2015 Jul 14.
• Background Atashkhoei S, Fakhari S, Pourfathi H, Bilehjani E, Garabaghi PM, Asiaei A. Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a double-blind randomised controlled trial. BJOG. 2017 Jan;124(2):292-298. doi: 10.1111/1471-0528.14416. Epub 2016 Nov 15.
• Background Farouk H, Shady N (2017) Intravenous Carbetocin to decrease blood loss during open myomectomy: a randomized placebo-controlled study. IJRCOG 7:
• Background Gad Allah, S. H., A Wali, A., & Mostafa, S. (2015). Hemostatic effect and postoperative benefits of intramyometrial carbetocin injection during myomectomy: a randomized controlled trial. Evidence Based Women's Health Journal, 5(4), 185-189.
• Background Gharabaghi PM, Alizadeh S, Atashkhoye S, Sayyah-Melli M, Jafari- Shobeiri M, Ouladsahebmadarek E, et al. Comparing the Outcomes and Side Effects of Administration of a Single Preoperative Dose of Vaginal Misoprostol With Intraoperative Oxytocin Infusion in Blood Loss During Abdominal Myomectomy. Int J Women's Health Reprod Sci 2017;
• Background Kongnyuy EJ, Wiysonge CS. Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev. 2014 Aug 15;2014(8):CD005355. doi: 10.1002/14651858.CD005355.pub5.
• Background Ragab A, Khaiary M, Badawy A. The Use of Single Versus Double Dose of Intra-vaginal Prostaglandin E2 "Misoprostol" prior to Abdominal Myomectomy: A Randomized Controlled Clinical Trial. J Reprod Infertil. 2014 Jul;15(3):152-6.

Drugs

Indications