drugset / Trial / NCT04597099
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
Phase 0
Unknown
10 enrolled
University of Virginia
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab
RandomizedCrossoverTriple-blindBasic science
Summary
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded, crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS, acute progesterone augmentation of FSH release (positive feedback) will be enhanced by flutamide.
Timeline
- Start
- 2022-10-26
- Primary completion
- 2025-10-01
- Completion
- 2025-10-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | flutamide | Small molecule | 250 mg | Oral |
| Background | Estradiol | Other / unclassified | 0.2 mg | Other |
| Background | Progesterone | Other / unclassified | 100 mg | Oral |