drugset / Trial / NCT04605796

A Single-arm, Open-label, Multi-center Phase II Clinical Study to Evaluate the Safety and Efficacy of Toripalimab Injection (JS001) Combined With Bevacizumab as the First-line Therapy for Advanced Hepatocellular Carcinoma (HCC)

NCT04605796 ↗

Phase 2 Completed 54 enrolled Shanghai Junshi Bioscience Co., Ltd.
NaSingle-groupOpen-labelTreatment

Summary

This is an open-label, single-arm, national multicenter phase II clinical study to preliminarily observe and evaluate the efficacy and safety of Toripalimab combined with Bevacizumab as the first-line therapy for advanced HCC The study will use safety/tolerability and ORR as the primary study objectives and indicators, and plans to enroll about 50-60 patients.

Timeline

Start
2020-04-10
Primary completion
2022-10-27
Completion
2023-05-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Bevacizumab Monoclonal antibody — —
Subject Lenvatinib Small molecule 15 mg/kg Intravenous
Subject Toripalimab Monoclonal antibody 240 mg Intravenous