Losartan Effects on Emotion-memory Interaction

Unknown 60 enrolled University of Electronic Science and Technology of China

RandomizedParallel-groupDouble-blindBasic science

Summary

The purpose of this study is to investigate whether a single dose of losartan (50 mg) can affect emotion-memory interaction in healthy humans and its underlying neural mechanisms.

Timeline

Start: 2020-10-10
Primary completion: 2021-12-31
Completion: 2022-03-31

Publications

Xu T, Zhou X, Jiao G, Zeng Y, Zhao W, Li J, Yu F, Zhou F, Yao S, Becker B. Angiotensin Antagonist Inhibits Preferential Negative Memory Encoding via Decreasing Hippocampus Activation and Its Coupling With the Amygdala. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Oct;7(10):970-978. doi: 10.1016/j.bpsc.2022.05.007. Epub 2022 May 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Losartan	Other / unclassified	50 mg	Oral

Indications

No indication recorded.