drugset / Trial / NCT04621500
Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Phase 2
Completed
60 enrolled
Medical University of South Carolina
National Institute on Minority Health and Health Disparities (NIMHD) · collabRalph H. Johnson VA Medical Center · collab
NaSingle-groupOpen-labelBasic science
Summary
Veterans between the ages of 50-75, who are having a prostate biopsy, will be recruited for their permission to collect an extra biopsy core for RNA-sequencing. If the participants' treatment decision is Active Surveillance, they will be enrolled into the intervention phase of the study. They will receive supplementation with Vitamin D3 (4,000 IU) daily with repeat (surveillance) prostate biopsy one year later. At that time an extra prostate sample core will be collected for RNA-sequencing to determine changes over time. Measurements for allostatic load (body stress/inflammatory markers) will also be collected at the time of enrollment and at the repeat prostate biopsy visit.
Timeline
- Start
- 2019-06-04
- Primary completion
- 2022-02-04
- Completion
- 2022-02-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cholecalciferol | Other / unclassified | 4000 iu | — |