Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose

Summary

This study evaluates direct switching vs use of a bridging dose from insulin glargine to insulin degludec in type 1 DM patients. Half of the participants will receive a bridging insulin glargine dose along with the 1st dose of degludec, while other half will receive a placebo and 1st dose of degludec.

Timeline

Start

2020-02-14

Primary completion

2022-09-07

Completion

2023-12-31

Publications

• Thirumalai A, Chao JH, Kaleru T, Dong X, Mandava P, Khakpour D, Hirsch IB. Bridging dose of U-100 glargine with first dose of insulin degludec improves glycaemia in the 48 h after transition in twice-daily glargine users. Diabetes Obes Metab. 2024 May;26(5):1868-1876. doi: 10.1111/dom.15502. Epub 2024 Feb 28.

Drugs

Indications