drugset / Trial / NCT04656028
Genetic Testing and Motivational Counseling for FH
Active not recruiting
180 enrolled
National Medical Research Center for Therapy and Preventive Medicine
Moscow State University of Medicine and Dentistry · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
To date, there are highly effective lipid-lowering drugs, the combination of which makes it possible to achieve the target level of LDL-C in most patients with familial hypercholesterolemia (FH). However, the effectiveness of treatment of FH patients strongly depends on adherence to lipid-lowering therapy and to the healthy lifestyle, as well as the detection of the disease and the therapy prescription as early as possible, better in childhood. The aim of the study is to assess the impact of genetic testing and motivational counseling on the effectiveness of treatment and cascade screening in patients with FH.
Timeline
- Start
- 2020-06-15
- Primary completion
- 2025-01-30
- Completion
- 2025-03-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Alirocumab | Monoclonal antibody | — | — |
| Background | Atorvastatin | Small molecule | — | — |
| Background | Evolocumab | Monoclonal antibody | — | — |
| Background | Ezetimibe | Unknown | — | — |
| Background | Rosuvastatin | Small molecule | — | — |