drugset / Trial / NCT04665609

Thermal Ablation Combined With Anlotinib and TQB2450 Solution for HCC

NCT04665609

Phase 3 Unknown 80 enrolled Chinese PLA General Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

In this study, investigators aimed to evaluated the efficacy and safety of microwave ablation combined with anlotinib and TQB2450 Solution in patients with advanced hepatocellular carcinoma. Patients were randomly assigned at a one-to-one ratio to receive microwave ablation plus anlotinib and TQB2450 Solution or microwave ablation plus TQB2450 Solution. Primary end points were objective response rate(ORR). Second end points include overall survival, progression-free survival and disease control rate. Safety was assessed in all patients.

Timeline

Start
2021-03-05
Primary completion
2022-12-31
Completion
2023-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Catequentinib Small molecule 12 mg Oral
Comparator Benmelstobart Monoclonal antibody 1200 mg Intravenous