drugset / Trial / NCT04665609
Thermal Ablation Combined With Anlotinib and TQB2450 Solution for HCC
RandomizedParallel-groupOpen-labelTreatment
Summary
In this study, investigators aimed to evaluated the efficacy and safety of microwave ablation combined with anlotinib and TQB2450 Solution in patients with advanced hepatocellular carcinoma. Patients were randomly assigned at a one-to-one ratio to receive microwave ablation plus anlotinib and TQB2450 Solution or microwave ablation plus TQB2450 Solution. Primary end points were objective response rate(ORR). Second end points include overall survival, progression-free survival and disease control rate. Safety was assessed in all patients.
Timeline
- Start
- 2021-03-05
- Primary completion
- 2022-12-31
- Completion
- 2023-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Catequentinib | Small molecule | 12 mg | Oral |
| Comparator | Benmelstobart | Monoclonal antibody | 1200 mg | Intravenous |