Drugs / Benmelstobart
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Benmelstobart

Monoclonal antibody targets CD274

Developed for
non-small cell lung carcinoma · small cell lung carcinoma · hepatocellular carcinoma · endometrial cancer · esophageal squamous cell carcinoma · gastric cancer · head and neck squamous cell carcinoma · triple-negative breast carcinoma
+35 more · biliary tract cancer · cancer · gastroesophageal adenocarcinoma · gastroesophageal junction adenocarcinoma · hormone receptor-positive breast cancer · malignant pancreatic neoplasm · neoplasm · adenocarcinoma · alveolar soft part sarcoma · biliary tract neoplasm · breast cancer · cholangiocarcinoma · chronic hepatitis B virus infection · clear cell renal carcinoma · digestive system neoplasm · fallopian tube cancer · female breast carcinoma · female reproductive organ cancer · gastroesophageal cancer · kidney cancer · lung cancer · mature T-cell and NK-cell non-Hodgkin lymphoma · melanoma · nasopharyngeal carcinoma · neoplasm of esophagus · non-small cell squamous lung carcinoma · oral cavity cancer · ovarian cancer · pheochromocytoma · primary mediastinal large B-cell lymphoma · primary peritoneal carcinoma · pulmonary large cell neuroendocrine carcinoma · renal cell carcinoma · thyroid cancer · uterine corpus sarcoma
Investigated by
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Fudan University · Henan Cancer Hospital · Shanghai Pulmonary Hospital, Shanghai, China · Sun Yat-sen University · The First Affiliated Hospital of Zhengzhou University
+30 more · Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. · Peking University · RenJi Hospital · Shanghai Zhongshan Hospital · Tang-Du Hospital · Tianjin Medical University Cancer Institute and Hospital · Yayi He · Chinese Academy of Medical Sciences · Chinese PLA General Hospital · First Affiliated Hospital of Zhejiang University · Huadong Hospital · Jiangsu Cancer Institute & Hospital · Jiangsu Provincial Stomatological Hospital · Jiangxi Provincial Cancer Hospital · Jinming Yu · Nanfang Hospital, Southern Medical University · Peking Union Medical College Hospital · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · The First Affiliated Hospital of Guangzhou Medical University · The First Affiliated Hospital with Nanjing Medical University · The Second Affiliated Hospital of Shandong First Medical University · The Third Xiangya Hospital of Central South University · Tongji Hospital · Xianhai Mao · Xijing Hospital · Xinqiao Hospital of Chongqing · Yongxu Jia

Trials 85 · started per year

today
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2018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT05942508 May 2023 → Feb 2026 small cell lung carcinoma Jinming Yu Unknown No outcome recorded
Phase 1 NCT06116240 Sep 2022 → Dec 2023 cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03897283 Jun 2019 → Jun 2020 cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03910127 Jun 2019 → Dec 2020 non-small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03855358 May 2019 → Jun 2020 triple-negative breast carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03460457 Mar 2018 → Mar 2019 neoplasm Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/29 trials
Phase 1/2 NCT05608785 Jan → Dec 2023 gastric cancer, gastroesophageal cancer Henan Cancer Hospital Unknown No outcome recorded
Phase 1/2 NCT05645315 Apr 2022 → Dec 2023 neoplasm Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT05139082 Nov 2021 → Oct 2023 digestive system neoplasm Peking University Unknown No outcome recorded
Phase 1/2 NCT04888546 Apr 2021 → Jul 2024 hepatocellular carcinoma Chinese Academy of Medical Sciences Unknown No outcome recorded
Phase 1/2 NCT04236362 Feb 2020 → Dec 2021 female reproductive organ cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03996408 Jun 2019 → Dec 2020 cholangiocarcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03991975 Jun 2019 → Mar 2020 melanoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03983928 Jun 2019 → Oct 2020 lung cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03825705 Apr 2019 → Jan 2021 adenocarcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 251 trials
Phase 2 NCT07627464 May 2026 → Dec 2028 expected renal cell carcinoma Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07602101 May 2026 → Dec 2027 expected clear cell renal carcinoma RenJi Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07643350 May 2026 → May 2029 expected non-small cell lung carcinoma The Third Xiangya Hospital of Central South University Not yet recruiting No outcome recorded
Phase 2 NCT07510594 May → Dec 2026 expected pulmonary large cell neuroendocrine carcinoma Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07538258 Apr 2026 → Sep 2027 expected small cell lung carcinoma Yayi He Not yet recruiting No outcome recorded
Phase 2 NCT07538271 Apr 2026 → Sep 2027 expected small cell lung carcinoma Yayi He Not yet recruiting No outcome recorded
Phase 2 NCT07537777 Apr 2026 → Jan 2028 expected hepatocellular carcinoma Nanfang Hospital, Southern Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07548177 Apr 2026 → Nov 2027 expected alveolar soft part sarcoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07193186 Apr 2026 → Dec 2029 expected thyroid cancer Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT07489300 Mar 2026 → Jan 2027 expected fallopian tube cancer, ovarian cancer, primary peritoneal carcinoma Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07535567 May 2026 → Dec 2028 expected head and neck squamous cell carcinoma Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Not yet recruiting No outcome recorded
Phase 315 trials
Phase 3 NCT07446335 Apr 2026 → Dec 2028 expected esophageal squamous cell carcinoma The First Affiliated Hospital of Zhengzhou University Not yet recruiting No outcome recorded
Phase 3 NCT06955325 May 2025 → Dec 2030 expected non-small cell lung carcinoma The First Affiliated Hospital of Guangzhou Medical University Not yet recruiting No outcome recorded
Phase 3 NCT06469879 Sep 2024 → Sep 2026 expected small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT06475599 Jul 2024 → Dec 2027 expected endometrial cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT05922345 Jun 2023 → Aug 2025 non-small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 3 NCT05718167 Feb 2023 → Oct 2024 non-small cell squamous lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 3 NCT05346952 Jan 2022 → Dec 2023 non-small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 3 NCT05145218 Sep 2021 → Oct 2024 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04964479 Aug 2021 → Dec 2022 non-small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04809142 Feb 2021 → Mar 2022 biliary tract cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT06931145 Apr 2025 → Apr 2027 expected small cell lung carcinoma Peking Union Medical College Hospital Not yet recruiting No outcome recorded
Phase not applicable2 trials
NCT06603974 Oct 2024 → Jul 2026 overdue gastric cancer Xijing Hospital Not yet recruiting No outcome recorded
NCT04891900 May 2021 → Dec 2024 gastric cancer, gastroesophageal junction adenocarcinoma Henan Cancer Hospital Unknown No outcome recorded
Also used as a comparator or background therapy in 7 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/23 trials
Phase 1/2 NCT07371663 Background Dec 2025 → Sep 2028 expected endometrial cancer, gastric cancer, melanoma, non-small cell lung carcinoma Beijing Tide Pharmaceutical Co., Ltd Recruiting No outcome recorded
Phase 1/2 NCT05859373 Background Jun 2023 → Sep 2024 non-small cell lung carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT04611711 Background Nov → Dec 2020 digestive system cancer Peking University Unknown No outcome recorded
Phase 22 trials
Phase 2 NCT07172412 Background Nov 2025 → Dec 2027 expected small cell lung carcinoma Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06141226 Background Apr 2023 → Dec 2027 expected non-small cell lung carcinoma Tianjin Medical University Cancer Institute and Hospital Recruiting No outcome recorded
Phase 32 trials
Phase 3 NCT07385079 Background Mar 2026 → Jan 2028 expected nasopharyngeal carcinoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 3 NCT04665609 Comparator Mar 2021 → Dec 2022 hepatocellular carcinoma Chinese PLA General Hospital Unknown No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 97 sources stand behind the page.

FieldValueCited text
Known as benmelstobart “The ETER701 study showed that Benmelstobart (TQB2450, an anti-PD-L1 antibody) combined with Anlotinib and chemotherapy achieved the longest progression-free survival (PFS) and...” PMID 40114144 Mar 2025
39

“Patients randomly received benmelstobart and anlotinib plus etoposide/carboplatin (EC; n = 246), placebo and anlotinib plus EC (n = 245) or double placebo plus EC ('EC alone'; n = 247)” PMID 38992123 Jul 2024

“TQB2450 (benmelstobart) is a novel humanized immunoglobulin G1 monoclonal antibody against programmed death-ligand 1 (PD-L1).” PMID 39507039 Oct 2024

Benmelstobart (TQB2450) is a humanized monoclonal antibody” NCT06914297

NCT06955325

NCT07294261

NCT07172412

NCT06874933

NCT07193186

NCT07643350

NCT07627464

NCT07537777

NCT06897579

NCT06733051

NCT07548177

NCT06953843

NCT06621095

NCT05582499

NCT06767800

NCT07535567

NCT07109167

NCT07489300

NCT06931145

NCT06992336

NCT06699498

NCT07371663

NCT06848439

NCT07385079

NCT06851169

NCT06496490

NCT06662006

NCT06528847

NCT07538271

NCT07446335

NCT06429397

NCT06978153

NCT07510594

NCT06637163

NCT07538258

NCT06603974

Known as Anicol “Piamprilizumab (Anicol) is a new PD-1 monoclonal antibody developed by Zhengda Tianqing Pharmaceutical Group Co., LTD.” NCT06429397
Known as APL-502 ChEMBL registry synonym — accepted as the source's own label CHEMBL5315042
Known as Benmelstobart Injection “The purpose of this study is to evaluate the efficacy and safety of Benmelstobart Injection combined with Anlotinib Hydrochloride and chemotherapy as first-line treatment for...” NCT07510594
1

benmelstobart injection, intravenous infusion” NCT06897579

Known as CBT-502 ChEMBL registry synonym — accepted as the source's own label CHEMBL5315042
Known as Piamprilizumab Piamprilizumab (Anicol) is a new PD-1 monoclonal antibody developed by Zhengda Tianqing Pharmaceutical Group Co., LTD.” NCT06429397
Known as TQB-2450 TQB-2450 is a humanized mAb of PD-L1 that prevents PD-L1 from binding to PD-1 and B7.1 receptors on the T cell surface, enabling T cells to restore immune activity and thus...” NCT05111366
58

“Surgery or Radiotherapy After PD-L1 Inhibitor (TQB-2450) and Chemotherapy Induction Therapy in Patients With Limited-stage Small-cell Lung Cancer” NCT04539977

“21 days as a treatment cycle, Anlotinib 12 mg/day, Orally (D1-D14); TQB 2450 1200 mg, iv (D1).” NCT05252078

NCT05859373

NCT05812430

NCT03825705

NCT03996408

NCT03855358

NCT03855384

NCT05111366

NCT06475599

NCT04236362

NCT04611711

NCT05718167

NCT05913089

NCT06469879

NCT06031480

NCT06939452

NCT04665609

NCT04234607

NCT05346952

NCT05922345

NCT05608785

NCT05645315

NCT04964479

NCT05038813

NCT04623333

NCT04405505

NCT07602101

NCT06116240

NCT05013697

NCT03910127

NCT03800706

NCT04306926

NCT04539977

NCT04895345

NCT06914297

NCT05311319

NCT04325763

NCT06141226

NCT06109402

NCT04202653

NCT04002622

NCT03897283

NCT06222944

NCT03460457

NCT06475287

NCT03983928

NCT04809142

NCT05252078

NCT04888546

NCT05145218

NCT04523272

NCT05942508

NCT04574284

NCT04891900

NCT05481645

NCT05139082

NCT03991975

Known as TQB2450 injection TQB2450 injection (1200mg ivgtt, q3W)” NCT04888546
Known as TQB2450 solution TQB2450 solution is a new novel of PD-L1 inhibitor made by Crown Bioscience and CHIATAI TIANQING(CTTQ PHARMA).” NCT04665609
Action Inhibit “prevents PD-L1 from binding to PD-1 and B7.1 receptors on T cell surface” NCT03825705
Modality Monoclonal antibody “TQB2450, a novel monoclonal antibody targeting programmed cell death ligand 1, has shown safety and efficacy in preclinical studies.” PMID 38188467 Jan 2024
Route Intravenous “eligible patients with advanced malignant tumors received intravenous TQB2450 once every 3 weeks.” PMID 38188467 Jan 2024
Target CD274 “TQB2450 solution is a new novel of PD-L1 inhibitor made by Crown Bioscience and CHIATAI TIANQING(CTTQ PHARMA).” NCT04665609