drugset / Trial / NCT06637163
Benmelstobart Combined With Radiochemotherapy as Neoadjuvant Treatment Iin ESCC
RandomizedParallel-groupOpen-labelTreatment
Summary
This study will explore the efficacy and safety of benmelstobart combined with radiochemotherapy compared to radiochemotherapy alone as neoadjuvant treatment for esophageal squamous cell carcinoma. It will also compare the effectiveness and safety of low-dose radiotherapy versus standard-dose radiotherapy in neoadjuvant regimens that include benmelstobart with concurrent radiochemotherapy. This research may provide more treatment options for patients with esophageal squamous cell carcinoma.
Timeline
- Start
- 2024-10-24
- Primary completion
- 2026-04
- Completion
- 2027-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Benmelstobart | Monoclonal antibody | 1200 mg | Intravenous |
| Comparator | Carboplatin | Small molecule | 2 unknown | Intravenous |
| Comparator | Paclitaxel | Small molecule | 50 mg/m2 | Intravenous |