drugset / Trial / NCT06637163

Benmelstobart Combined With Radiochemotherapy as Neoadjuvant Treatment Iin ESCC

NCT06637163

Phase 2 Recruiting 100 enrolled Shanghai Zhongshan Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

This study will explore the efficacy and safety of benmelstobart combined with radiochemotherapy compared to radiochemotherapy alone as neoadjuvant treatment for esophageal squamous cell carcinoma. It will also compare the effectiveness and safety of low-dose radiotherapy versus standard-dose radiotherapy in neoadjuvant regimens that include benmelstobart with concurrent radiochemotherapy. This research may provide more treatment options for patients with esophageal squamous cell carcinoma.

Timeline

Start
2024-10-24
Primary completion
2026-04
Completion
2027-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Benmelstobart Monoclonal antibody 1200 mg Intravenous
Comparator Carboplatin Small molecule 2 unknown Intravenous
Comparator Paclitaxel Small molecule 50 mg/m2 Intravenous