Comparing TAP Blocks Bupivacaine, and Placebo for Plane

Phase 3 Completed 285 enrolled Edward Mascha

RandomizedParallel-groupTriple-blindPrevention

Summary

The study will prospectively compare the analgesic efficacy of TAP blocks with liposomal bupivacaine, plain bupivacaine, and placebo in patients who are scheduled for major abdominal surgery. The primary aim is to assess the duration of the local analgesia (determined by pinprick and cold) in all four quadrants. Comparing opioid consumption and pain scores is a secondary aim. All aims will be assessed over 72 hours or the duration of hospitalization if shorter.

Timeline

Start: 2021-06-04
Primary completion: 2024-02-20
Completion: 2024-02-20

Publications

Turan A, Ali Sakr Esa W, Brooker J, Rosen MJ, Ekrami E, Tok Cekmecelioglu B, Nair H, Al Jarkas A, Shah K, Mueller C, Valente M, El Hage Chehade N, Sessler DI; CLEVELAND Trial Group. Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks: The CLEVELAND Randomized Trial. Anesthesiology. 2026 Mar 1;144(3):546-558. doi: 10.1097/ALN.0000000000005869. Epub 2025 Dec 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupivacaine	Other / unclassified	20 ml	Other
Comparator	Bupivacaine	Other / unclassified	50 ml	Other

Indications

No indication recorded.