drugset / Trial / NCT04700007
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
NaSingle-groupOpen-labelBasic science
Summary
The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in the mechanism of morphine-induced mast cell degranulation. Moreover, we also aim to clarify if the mechanism of opioid-induced itch relay on the histaminergic pathway by using the antihistamine (diphenhydramine) to suppress the release of histamine from peripheral mast cells.
Timeline
- Start
- 2021-01-18
- Primary completion
- 2021-12-31
- Completion
- 2021-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Capsaicin | Small molecule | — | Topical |
| Subject | Diphenhydramine | Unknown | 1 % | Topical |
| Subject | Histamine | Small molecule | 1 % | Other |
| Subject | Morphine | Other / unclassified | 0.1 mg/ml | Other |
Indications
No indication recorded.