drugset / Trial / NCT04701281

Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer

NCT04701281

Phase 1/2 Terminated 5 enrolled AllVascular
NaSingle-groupOpen-labelTreatment

Summary

The treatment proposed in this trial is to administer intra-arterial chemotherapy to liver metastases from colorectal cancer when the blood flow to and from the liver has been isolated via balloon catheters through a vascular access system called the AVAS. The objective of this study is to evaluate the tumour response of repeated and isolated intra-arterial liver isolation oxaliplatin compared with the standard systemic chemotherapy (intravenous 5-FU + leucovorin + oxaliplatin \[FOLFOX\] or oral capecitabine with IV oxaliplatin \[XELOX\]).

Timeline

Start
2022-03-02
Primary completion
2022-09-19
Completion
2022-10-19

Drugs

EvaluationDrugModalityDoseRoute
Subject Oxaliplatin Small molecule 50 mg/m2 Other
Background Capecitabine Small molecule 1000 mg/m2 Oral