Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19

Phase 4 Completed 110 enrolled University of Oklahoma

RandomizedParallel-groupOpen-labelTreatment

Summary

This open label clinical trial is to evaluate two different doses of dexamethasone on the health outcome using World Health Organization ordinal scale at day 28 in hospitalized patients with COVID-19.

Timeline

Start: 2021-01-21
Primary completion: 2021-12-31
Completion: 2022-03-04

Outcome

Missed primary endpoint

paper Treatment with dexamethasone 20 mg daily compared with dexamethasone 6 mg daily did not result in better clinical improvement PMID 36190994 ↗

Publications

Wu H, Daouk S, Kebbe J, Chaudry F, Harper J, Brown B. Low-dose versus high-dose dexamethasone for hospitalized patients with COVID-19 pneumonia: A randomized clinical trial. PLoS One. 2022 Oct 3;17(10):e0275217. doi: 10.1371/journal.pone.0275217. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	6 mg	—
Subject	Dexamethasone	Small molecule	10 mg	—