Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma

Summary

This clinical trial measures the amount and effect of lidocaine injected into patients with glioblastoma while they are undergoing surgical removal of their brain tumors. Lidocaine is a substance used to relieve pain by blocking signals at the nerve endings in skin. Information gained from this study may help researchers come up with new treatments to help patients with glioblastomas in the future.

Timeline

Start

2021-01-20

Primary completion

2021-12-26

Completion

2022-01-24

Publications

• Riestenberg RA, Goodarzi A, Goodrich D, Clouse J, Ling S, Lechpammer M, Schloemerkemper N, Chen S, Chen Y, Bloch O, Shahlaie K. Pharmacokinetics of lidocaine infusion during surgery for glioblastoma. Clin Neurol Neurosurg. 2025 Dec;259:109218. doi: 10.1016/j.clineuro.2025.109218. Epub 2025 Oct 26.

Drugs

Indications