Influence of Bovine Lactoferrin on Feeding Intolerance and Intestinal Permeability in Preterm Neonates

Summary

Preterm infants are at increased risk of developing feeding intolerance due to functional immaturity of their gastrointestinal tract and may lead to discontinuation of enterak feeding. Lactoferrin promotes the growth of probiotic bacteria, stimulates differntiation and proliferation of enterocytes and expression of intestinal digestive enzymes , lead to improvement of feeding intolerance. So we hypothesized that supplementation of bovine lactoferrin would be benificial on feeding intolerance and decrease intestinal permeability in preterm infants with feeding intolerance.

Timeline

Start

2020-12-15

Primary completion

2021-12

Completion

2022-06

Publications

• Ellakkany N, Abdel-Hady H, Eita AM, Mosaad YM, Megahed A. Influence of bovine lactoferrin on feeding intolerance and intestinal permeability in preterm infants: a randomized controlled trial. Eur J Pediatr. 2024 Nov 20;184(1):30. doi: 10.1007/s00431-024-05861-4.

Drugs

Indications

No indication recorded.