Drugs / Lactoferrin
Lactoferrin
also known as
lactotransferrin · pravotin · Apolactoferrin · Pravotin-sachets · Provan · recombinant human (rh) lactoferrin · red protein · rh-lactoferrin
Trials 24
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT07480434 | Oct 2024 → Mar 2025 | infectious disease with sepsis | Zartash Sial Paeds Med | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT03279536 | Nov 2017 → Dec 2018 | iron deficiency anemia | Woman's Health University Hospital, Egypt | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT07706582 | Nov 2025 → Sep 2026 overdue | end stage renal failure, iron deficiency anemia | Beni-Suef University | Active not recruiting | No outcome recorded |
| Phase 2 | NCT04412395 | Feb → Aug 2022 | COVID-19, Middle East respiratory syndrome, acute respiratory distress syndrome | National Research Centre, Egypt | Unknown | No outcome recorded |
| Phase 2 | NCT03481790 | Sep 2017 → Mar 2018 | iron deficiency anemia | Ain Shams Maternity Hospital | Completed | No outcome recorded |
| Phase 2/33 trials | ||||||
| Phase 2/3 | NCT04427865 | Jul → Sep 2020 | COVID-19 | Cairo University | Unknown | No outcome recorded |
| Phase 2/3 | NCT04421534 | Jun → Sep 2020 | COVID-19 | Cairo University | Unknown | No outcome recorded |
| Phase 2/3 | NCT04475120 | Apr → Jul 2020 | COVID-19 | University of Rome Tor Vergata | Completed | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT07502235 | Mar → Aug 2026 overdue | — | Ain Shams University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT05519254 | Mar 2023 → Jul 2026 overdue | diarrheal disease, protein-energy malnutrition | University of Washington | Recruiting | No outcome recorded |
| Phase 3 | NCT01382199 | Sep 2011 → Sep 2013 | diarrheal disease | Ventria Bioscience | Unknown | No outcome recorded |
| Phase 49 trials | ||||||
| Phase 4 | NCT05936528 | Sep 2025 → Jul 2026 | — | Mansoura University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT06427200 | Jul 2024 → Jul 2027 expected | symptomatic heart failure | Cairo University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05714176 | Feb 2023 → Jan 2024 | chronic kidney disease | Menoufia University | Unknown | No outcome recorded |
| Phase 4 | NCT03748043 | Feb → May 2019 | iron deficiency anemia | South Valley University | Unknown | No outcome recorded |
| Phase 4 | NCT04435574 | Sep 2018 → Apr 2019 | iron deficiency anemia | Cairo University | Completed | No outcome recorded |
| Phase 4 | NCT04082598 | Oct 2016 → Sep 2018 | — | Antonio Barone | Completed | No outcome recorded |
| Phase 4 | NCT02959229 | Aug 2014 → Dec 2015 | neonatal sepsis | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT02372942 | Feb 2014 → Nov 2019 | — | University of Padova | Unknown | No outcome recorded |
| Phase 4 | NCT01172236 | Jan 2011 → Jan 2012 | fetal growth restriction | University of Siena | Completed | No outcome recorded |
| Phase not applicable4 trials | ||||||
| — | NCT05434104 | Apr 2026 → Dec 2027 expected | bacterial vaginosis, vulvovaginal candidiasis | Guy's and St Thomas' NHS Foundation Trust | Recruiting | No outcome recorded |
| — | NCT07069140 | Jul 2025 → Jun 2026 overdue | gingivitis, pregnancy disorder | University of Pavia | Recruiting | No outcome recorded |
| — | NCT05431023 | Aug 2022 → Aug 2023 | pneumonia | Assiut University | Unknown | No outcome recorded |
| — | NCT04335058 | Jan 2020 → Oct 2023 | chronic liver failure, iron deficiency anemia | Post Graduate Institute of Medical Education and Research, Chandigarh | Unknown | No outcome recorded |
| Comparator or background therapy18 trials | ||||||
| Phase 0 | NCT04094597 Comparator | Jan → Dec 2018 | neonatal sepsis | Cairo University | Completed | No outcome recorded |
| Phase 1 | NCT06106880 Comparator | May 2022 → Apr 2023 | Achoo syndrome, common cold, headache disorder, pharyngitis +1 | Applied Biological Laboratories Inc | Completed | No outcome recorded |
| Phase 1/2 | NCT03484845 Comparator | Nov 2018 → Dec 2019 | iron deficiency anemia | Assiut University | Unknown | No outcome recorded |
| Phase 2 | NCT03759353 Comparator | Jan → Oct 2018 | iron deficiency anemia | Ain Shams University | Completed | No outcome recorded |
| Phase 2 | NCT01830595 Comparator | Sep 2014 → Jul 2017 | HIV infectious disease | Jason Baker | Completed | No outcome recorded |
| Phase 2 | NCT02695563 Comparator | Jan 2014 → Mar 2015 | pregnancy disorder | Università degli Studi di Ferrara | Completed | No outcome recorded |
| Phase 2/3 | NCT06181422 Comparator | Apr → Jun 2024 | infectious disease with sepsis | Tanta University | Unknown | No outcome recorded |
| Phase 2/3 | NCT05669963 Comparator | Jul 2022 → Jan 2023 | bacterial vaginosis | Zagazig University | Unknown | No outcome recorded |
| Phase 2/3 | NCT03940430 Comparator | Sep → Nov 2018 | iron deficiency anemia | yasmin gamal el gendy | Completed | No outcome recorded |
| Phase 3 | NCT05342272 Comparator | Sep 2017 → Jan 2018 | — | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | Completed | No outcome recorded |
| Phase 4 | NCT06491394 Comparator | Nov 2024 → Mar 2025 | myopathy | Aswan University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT05921968 Comparator | Jul 2023 → Jan 2024 | iron deficiency anemia | Ain Shams University | Unknown | No outcome recorded |
| Phase 4 | NCT06252103 Comparator | May → Nov 2023 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT05900635 Comparator | Oct 2022 → Jun 2023 | anemia due to chronic disorder | Alexandria University | Unknown | No outcome recorded |
| Phase 4 | NCT04014855 Comparator | Oct 2018 → Jul 2019 | obesity disorder | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT03542825 Comparator | Jan → Sep 2018 | iron deficiency anemia | South Valley University | Completed | No outcome recorded |
| — | NCT06590831 Comparator | Jun 2023 → Jun 2024 | iron deficiency anemia | Egymedicalpedia | Completed | No outcome recorded |
| — | NCT02843984 Comparator | Mar 2011 → Mar 2012 | pregnancy disorder | Università degli Studi di Ferrara | Completed | No outcome recorded |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 43 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Lactoferrin | “Lactoferrin, also known as the "red protein," is a cationic glycoprotein from the transferrin family with an exceptionally high affinity for iron-approximately 300 times...” NCT07706582 ↗41“tooth extraction and Amoxicillin- clavulanic acid 875/125 mg, twice a day, for 6 days + Bifidobacterium longum and Lactoferrin twice a day for 6days” NCT04082598 ↗ “The liquid spray contained wintergreen oil, menthol, lactoferrin, lysozyme, aloe, and glycerin.” NCT06106880 ↗ “Lactoferrin Versus Iron Supplement in Irondeficiency Anemia and Weight Loss in Obese Children” NCT04014855 ↗ “lactoferrin 100 mg per day plus ferric hydroxide polymaltose 6 mg /kilogram of Elemental iron” NCT03748043 ↗ “Lactoferrin (Difesan, vaginal tablets 300 mg); it is used in acute vaginosis” NCT02372942 ↗ “Lactoferrin vaginal pessaries to insert nightly for 21 nights” NCT05434104 ↗ “Lactoferrin (Apolactoferrin)” NCT04412395 ↗ |
| Known as | Apolactoferrin | “Lactoferrin (Apolactoferrin)” NCT04412395 ↗ |
| Known as | lactotransferrin | “Lactoferrin (formerly known as lactotransferrin) is a glycoprotein, and a member of a transferrin family” NCT03759353 ↗1“Lactoferrin (previously lactotransferrin)is a glycoprotein” NCT06590831 ↗ |
| Known as | pravotin | “lactoferrin only (pravotin 100mg ) twice daily for 4 weeks.” NCT06590831 ↗1“lactoferrin ( pravotin) 100mg twice daily” NCT03940430 ↗ |
| Known as | Pravotin-sachets | “20 patients were given lactoferrin 100mg (Pravotin-sachets®,100mg, Hygint, Egypt) with ferrous gluconate twice daily for 4 weeks Patients were assigned to take the medication...” NCT06252103 ↗ |
| Known as | Provan | “30 pediatric patients who will receive oral iron supported Lactoferrin (Provan) 100 mg/day for 12 weeks.” NCT05714176 ↗ |
| Known as | recombinant human (rh) lactoferrin | “A randomized placebo-controlled crossover clinical trial of recombinant human (rh) lactoferrin was conducted among 54 human immunodeficiency virus-infected participants with...” PMID 30721997 ↗ May 2019 |
| Known as | red protein | “Lactoferrin, also known as the "red protein," is a cationic glycoprotein from the transferrin family with an exceptionally high affinity for iron-approximately 300 times...” NCT07706582 ↗ |
| Known as | rh-lactoferrin | “A randomized placebo-controlled crossover clinical trial of recombinant human (rh) lactoferrin was conducted among 54 human immunodeficiency virus-infected participants with...” PMID 30721997 ↗ May 2019 |
| Action | Inhibit | “lactoferrin can inhibit SARS-CoV-2 invasion as in the case of SARS-CoV” NCT04421534 ↗ |
| Modality | Protein / enzyme biologic | “The lactoferrin is an iron-binding protein, naturally found in high concentrations in breast milk” NCT01172236 ↗ |
| Route | Oral | “Administered Orally” NCT01382199 ↗ |