Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats

Summary

This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1 signalling pathway. The main questions it aims to answer are: 1. Is Lf administration 30 min. before or after RM induction in rats beneficial to kidneys and heart? 2. When administered to glycerol-induced rats, does Lf act by upregulating the AMPK/Nrf2/ HO-1 signalling pathway and inhibiting ferroptosis?

Timeline

Start

2024-11-01

Primary completion

2025-03-01

Completion

2025-04-01

Drugs

Indications