Intrathecal Opioids for Colorectal Resection

NCT04752033 ↗

Phase 4 Completed 80 enrolled Mayo Clinic

RandomizedSequentialTriple-blindTreatment

Summary

This research study is being done to determine the optimal dose of spinal morphine and hydromorphone in patients undergoing minimally-invasive (i.e., surgery performed through small entry sites and using cameras) colorectal surgery.

Timeline

Start: 2021-03-10
Primary completion: 2023-02-17
Completion: 2023-02-17

Publications

Vinsard PA, Pleticha J, Sharpe EE, Panchamia JK, Olsen DA, Sviggum HP, Shawki SF, Behm KT, Larson DW, LeMahieu AM, Niesen AD, Amundson AW. A Prospective Randomized Dose-Finding Study of Intrathecal Opioids for Postoperative Analgesia After Minimally Invasive Colorectal Operation. Mayo Clin Proc Innov Qual Outcomes. 2025 Mar 3;9(2):100600. doi: 10.1016/j.mayocpiqo.2025.100600. eCollection 2025 Apr.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydromorphone	Other / unclassified	—	Other
Subject	Morphine	Other / unclassified	—	Other

Indications

No indication recorded.