Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly

Phase 4 Completed 114 enrolled Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Instituto de Investigación Biomédica de Salamanca · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Prospective, low-level, non-commercial intervention, comparative clinical trial (phase IV) of balanced, randomized groups, to compare the analgesic efficacy of the local anesthetics Ropivacaine and Levobupivacaine in peripheral nerve block in hip fracture surgery in the elderly .

Timeline

Start: 2021-02-13
Primary completion: 2021-11-26
Completion: 2021-12-01

Outcome

Missed primary endpoint

paper There were no statistically significant differences in analgesic duration between levobupivacaine (median 861.0, IQR 960) and ropivacaine (median 1205.0, IQR 1379; p = 0.069). PMID 38337464 ↗

Publications

Results Salgado-Garcia D, Diaz-Alvarez A, Gonzalez-Rodriguez JL, Lopez-Iglesias MR, Sanchez-Lopez E, Sanchez-Ledesma MJ, Martinez-Trufero MI. Comparison of the Analgesic Efficacy between Levobupivacaine 0.25% and Ropivacaine 0.375% for PENG (Pericapsular Nerve Group) Block in the Context of Hip Fracture Surgery of Elderly Patients: A Single-Center, Randomized, and Controlled Clinical Trial. J Clin Med. 2024 Jan 29;13(3):770. doi: 10.3390/jcm13030770.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levobupivacaine	Other / unclassified	0.25 %	—
Subject	Levobupivacaine	Other / unclassified	7.5 mg/ml	—
Subject	Levobupivacaine	Other / unclassified	20 ml	—
Subject	Ropivacaine	Other / unclassified	0.375 %	—
Subject	Ropivacaine	Other / unclassified	2 mg/ml	—
Subject	Ropivacaine	Other / unclassified	20 ml	—