drugset / Trial / NCT04782856
Energy Metabolism in Thyroidectomized Patients
Phase 2
Completed
13 enrolled
Virginia Commonwealth University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this research study is to measure the changes in energy metabolism (how the body burns energy), cardiovascular function (heart function), and lipid metabolism (cholesterol break down and building) before and after thyroidectomy (surgical removal of thyroid gland) in response to two approved therapies for hypothyroidism: levothyroxine (LT4) or Liothyronine/levothyroxine (LT3/LT4) combination therapy.
Timeline
- Start
- 2020-10-28
- Primary completion
- 2023-04-19
- Completion
- 2023-04-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Levothyroxine | Other / unclassified | 1.6 ug/kg | Oral |
| Subject | Levothyroxine | Other / unclassified | 25 ug | Oral |
| Subject | Liothyronine | Small molecule | 5 ug | Oral |