Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

Phase 4 Recruiting 171 enrolled University of Minnesota Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab

Non-randomizedParallel-groupOpen-labelPrevention

Summary

The investigators aim to address the following specific aims: * Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors. * Examine the effects of this maternal smoking intervention on infant health. * Examine racial and ethnic differences in intervention outcomes.

Timeline

Start: 2022-04-14
Primary completion: 2027-06-02
Completion: 2027-06-02

Publications

Abdelwahab N, Allen A, Harrison K, Petersen A, Allen S. A protocol for modifying progesterone to increase postpartum cigarette smoking abstinence and reduce secondhand smoke exposure in infants. Contemp Clin Trials Commun. 2024 Nov 6;42:101389. doi: 10.1016/j.conctc.2024.101389. eCollection 2024 Dec.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Progesterone	Other / unclassified	200 mg	Oral

Indications

No indication recorded.